Enigmatic Kikuchi-Fujimoto Disease: A Comprehensive Review

Xavier Bosch, MD; Antonio Guilabert, MD; Rosa Miquel, MD; Elias Campo, MD

Disclosures

Am J Clin Pathol. 2004;122(1) 

In This Article

Conclusions

KFD is an extremely uncommon, self-limited, and perhaps underdiagnosed process of unknown cause with an excellent prognosis that seems to be more prevalent among Asiatic people. The clinical, histopathologic, and immunohistochemical features seem to point to a viral cause, an extreme that has not been proven. Recognition of this condition is crucial, especially because it can be mistaken for malignant lymphoma or, rarely, adenocarcinoma. Awareness of this disorder not only by clinicians but also by pathologists might help prevent misdiagnosis and inappropriate treatment. The diagnosis of KFD merits active consideration in any nodal biopsy showing fragmentation, necrosis, and karyorrhexis, especially in young people with posterior cervical lymphadenopathy.

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