Cytochrome P450 1A2 (CYP1A2) Activity and Risk Factors for Breast Cancer: A Cross-Sectional Study

Chi-Chen Hong; Bing-Kou Tang; Geoffrey L Hammond; David Tritchler; Martin Yaffe; Norman F Boyd


Breast Cancer Res. 2004;6(4) 

In This Article


Results from the present cross-sectional study suggests that several factors associated with breast cancer risk are associated with CYP1A2 activity, including SHBG and free estradiol levels, insulin and IGF-1, blood lipids and cholesterol, body size, and smoking status. Some of the observed associations, however, were contrary to hypothesized directions and suggest that increased CYP1A2 function may be associated with increased risk for breast cancer. These preliminary findings need confirmation in future studies. The association of risk factors with the activity of metabolic enzymes, particularly those under substantial genetic control, may suggest important pathways in the development of breast cancer. Further research is required to elucidate the relationships between CYP1A2 genotype, CYP1A2 phenotype, their influence on risk factors associated with breast cancer, and their impact on breast cancer risk.

None declared.

Norman F Boyd,

This research article is open access, which means it is universally and freely accessible via the Breast Cancer Research website, deposited in at least one widely and internationally recognized open access repository (such as PubMed Central), and the copyright rests with the authors.

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