Resistance to ACTH Action
ACTH has an important tropic effect on adrenal development via the melanocortin-2 receptor (MC2R, ACTH receptor) and subsequent downstream signalling pathways. Abnormalities in these signalling processes result in adrenal hypoplasia due to ACTH resistance.
Clin Endocrinol. 2004;60(5) © 2004 Blackwell Publishing
Cite this: Inherited Adrenal Hypoplasia: Not Just for Kids! - Medscape - May 01, 2004.