Arginine Immunonutrition in Critically Ill Patients: A Clinical Dilemma

Joyce K. Stechmiller, PhD, ARNP; Beverly Childress, MSN; Tricia Porter, BSN


Am J Crit Care. 2004;13(1) 

In This Article


The benefits of enteral immunonutrition with arginine are most significant in surgical patients. Unfortunately, questions still exist about the effect of treatment with immunonutritional formulas containing arginine in critically ill patients, and further research is necessary to determine underlying mechanisms by which arginine may be deleterious. Sound nursing practice is guided by scientific rationale for therapy. Current research does not support the use of currently available immunonutritional formulas with arginine in most critically ill patients experiencing SIRS, sepsis, or organ failure.


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