Highlights From The First World Congress on the Insulin Resistance Syndrome

Zachary T. Bloomgarden, MD


January 29, 2004

In This Article

The IRS and Hypertension

Dr. Gerald Reaven discussed the relationship of the IRS to hypertension,[47] a relationship that was first recognized in 1966.[48] Blood pressure levels are as strongly associated with insulin levels as with insulin resistance, as assessed by the clamp technique.[49] Insulin causes sodium retention, and Dr. Reaven noted that insulin resistance at the level of skeletal muscle is not associated with renal insulin resistance to urate reabsorption, so that in the presence of insulin resistance, hyperinsulinemia may lead to increased total body sodium. In a study from his group comparing persons with hypertension and normal vs ischemic change on electrocardiogram, the latter group showed greater insulin resistance, with hyperinsulinemia during a glucose tolerance test and lower HDL levels.[50]