Bronchiolitis Obliterans Syndrome Complicating Lung or Heart-Lung Transplantation

John A. Belperio, MD; Kathleen Lake, PharmD; Henry Tazelaar, MD; Michael P. Keane, MD; Robert M. Strieter, MD; Joseph P. Lynch, III, MD


Semin Respir Crit Care Med. 2003;24(5) 

In This Article


Management of BOS complicating LT is difficult because no treatment strategies have been proven to influence survival or long-term outcome ( Table 6 ). For patients failing aggressive medical therapy, retransplantation is an option, but given the limited number of donor organs, the ethics and role of retransplantation in this context are controversial. Ultimately, a greater understanding of the pathogenesis of BOS may allow development of novel therapeutic strategies that may improve outcome.


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