Ethylene Glycol Intoxication: Case Report and Pharmacokinetic Perspectives

Nina Vasavada, M.D.; Craig Williams, Pharm.D.; Richard N. Hellman, M.D.


Pharmacotherapy. 2003;23(12) 

In This Article


This clinical experience illustrates the efficacy of fomepizole monotherapy in a patient with elevated serum ethylene glycol concentration, normal kidney function, hemodynamic stability, and absence of acidosis at presentation. This case reaffirms recent data about the safety and efficacy of fomepizole therapy even in patients with serum ethylene glycol concentrations greater than 50 mg/dl.[16] Cost factors may favor ADH inhibition in conjunction with hemodialysis if only one session of hemodialysis and one day of hospitalization are required.


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