Latex Allergy

Erin M. Warshaw, MD

In This Article

Differential Diagnosis

If tests are negative and suspicion for type I allergy remains, consider evaluating for other types of urticaria. Nonimmunologic urticaria occurs without previous sensitization and can be caused by chemicals, which directly induce degranulation of mast cells. Sorbic acid, found in some glove powders, can induce nonimmunologic contact urticaria.

Immediate-type allergic reactions to rubber additives (which usually cause delayed-type hypersensitivity) have been reported.[35–37] The significance of these immediate reactions to rubber additives is uncertain; well-designed large studies are needed to rule out false positives due to contaminants.