Ischemia-Reperfusion Injury vs Early Acute Rejection?

Ron Shapiro, MD


November 11, 2003


How do you differentiate the diagnosis of ischemia-reperfusion injury from early acute rejection in a kidney transplant recipient?

Response from Ron Shapiro, MD

A kidney biopsy should be able to differentiate between early acute rejection and other pathologies, including ischemia-reperfusion-associated acute tubular necrosis (ATN). The biopsy findings for acute rejection would include tubulitis and other findings as described in the Banff criteria. The absence of findings consistent with acute rejection would rule it out; other histopathologic findings of ATN would be seen. The only way to know for sure is to perform a biopsy.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.
Post as: