Drug Therapy for the Management of Atrial Fibrillation: An Update

Andrew RJ Mitchell


Br J Cardiol. 2003;10(5) 

In This Article

Ventricular Rate Control

Sustained high ventricular rates during persistent or permanent AF can lead to a deterioration in left ventricular function.[10,11,12] Historically, digoxin has been used as the pharmacological agent of choice but it has been shown that digoxin, alone, is inadequate at controlling heart rate during exercise in many patients.[13] Beta blockers or rate controlling calcium antagonists, such as diltiazem or verapamil, are more effective at ventricular rate control.[14,15,16,17] Amiodarone has been shown to have some effects at controlling heart rate in AF, possibly via its weak beta-blocking properties, but only when given intravenously.[18,19]


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.
Post as: