The Prevalence of Elevated Serum C-Reactive Protein Levels in Inflammatory and Noninflammatory Thyroid Disease

Elizabeth N. Pearce, Fausto Bogazzi, Enio Martino, Sandra Brogioni, Enia Pardini, Giovanni Pellegrini, Arthur B. Parkes, John H. Lazarus, Aldo Pinchera, Lewis E. Braverman

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In This Article

Results

Of 93 euthyroid, nongoitrous control patients, 4.3% had serum CRP levels greater than 10 mg/L ( Table 2 ). This is consistent with previously published reports of the prevalence of CRP levels greater than 10 mg/L in randomly selected healthy blood donors.[28] None of the patients with nontoxic multinodular goiter (n = 34), or with toxic nodular goiter (n = 23) had CRP levels greater than 10 mg/L. Similarly, none of the patients with toxic diffuse goiter, either untreated (n = 49) or euthyroid on MMI (n = 33), had CRP greater than 10 mg/L.

Of 35 patients with Hashimoto's thyroiditis, all of whom were euthyroid (either spontaneously or during treatment with levothyroxine), 8.6% had CRP levels greater than 10 mg/L. This did not differ significantly from the control group. One of 38 thyroid cancer patients with short-term hypothyroidism after levothyroxine withdrawal after thyroidectomy (2.6%) had serum CRP greater than 10 mg/L, also not significantly different from the controls. Six of 7 patients (86%) with untreated subacute thyroiditis did have CRP levels greater than 10 mg/L (p < 0.00001).

In the patients with postpartum lymphocytic thyroiditis, 1 of 27 hypothyroid patients (4%) had CRP levels greater than 10 mg/L; 3 of 34 euthyroid patients (9%) had CRP levels greater than 10 mg/L; and 2 of 9 hyperthyroid patients (22%) had CRP levels greater than 10 mg/L. The occurrence of CRP levels greater than 10 mg/L in these three individual groups of women with postpartum thyroidtitis did not differ significantly from each other or from the control population.

Finally, 1 of 7 euthyroid patients treated with amiodarone (14%) had CRP levels greater than 10 mg/L, which did not differ significantly from the control group. Six of 31 patients with type I AIT (19%) and 4 of 33 patients with type II AIT (12%) had CRP levels greater than 10 mg/L. The occurrence of positive CRP values did not differ significantly between the 3 groups of amiodarone-treated patients. The occurrence of positive CRP values in type I AIT patients differed significantly from that observed in the controls (p = 0.02), but type II AIT patients did not.

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