BRCA2 Mutation Carriers, Reproductive Factors and Breast Cancer Risk

Laufey Tryggvadottir, Elinborg J Olafsdottir, Sigfridur Gudlaugsdottir, Steinunn Thorlacius, Jon G Jonasson, Hrafn Tulinius, Jorunn E Eyfjord


Breast Cancer Res. 2003;5(5) 

In This Article


The association between breast cancer risk and the number of pregnancies and between breast cancer risk and the duration of breast feeding differed among women with and without the BRCA2 mutation. The present study does not allow for differentiating between effect modification by mutation status on the one hand and inherited differences with respect to fertility or problems with breast feeding due to presence of the mutation on the other. Further studies are needed both on fertility and potential problems with breast feeding in unaffected mutation carriers, and on the effects of hormones related to pregnancy and breast feeding with respect to signalling and differentiation in breast epithelial cells of mutation carriers. In the context of current knowledge, however, the results are supportive of a hypothesis stating that the product of the BRCA2 gene has a function relating to the differentiation of epithelial tissue in the breast in response to the hormones of pregnancy.

None declared.

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