Alfuzosin Hydrochloride for the Treatment of Benign Prostatic Hyperplasia

Mary Lee

Disclosures

Am J Health Syst Pharm. 2003;60(14) 

In This Article

Chemistry

Alfuzosin, a 4-amino-2-piperazinyl quinazoline, is chemically related to prazosin. Its molecular formula is C19H27N5O4 HCl and molecular weight is 425.9. It is highly soluble in water.[9] Because of limited lipophilicity, it cannot easily penetrate the blood-brain barrier, as documented in experimental models using rats.[10] Therefore, alfuzosin has a lower potential to cause dizziness, asthenia, or somnolence than some of the other α1-adrenergic antagonists.

Alfuzosin is commercially available in Europe under multiple brand names, including Xatral (Synthelabo), Benestan (Alonga), Dalfaz (Synthelabo), Mittoval (Schering), Urion (Zambon), and UroXatral (Synthelabo).

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