Alfuzosin Hydrochloride for the Treatment of Benign Prostatic Hyperplasia

Mary Lee


Am J Health Syst Pharm. 2003;60(14) 

In This Article

Dosage and Administration

The dosage of IR alfuzosin hydrochloride ranges from 2.5 mg p.o. thrice daily to a maximum of 10-12 mg/day. Frequent daily administration is required because of alfuzosin's short serum half-life.

There are two ER formulations of alfuzosin hydrochloride. One formulation can be prescribed as a 10-mg tablet once daily and the other as a 5-mg tablet twice daily. Neither formulation requires dosage titration. Both ER formulations produce less cardiovascular adverse effects than the IR formulation and other second-generation α-adrenergic antagonists. The adverse effect profile of these ER formulations is similar to placebo.[84]

FDA is currently reviewing the once-a-day ER preparation for release onto the commercial market.

Common dosing regimens for various α1-adrenergic antagonists are summarized in Table 5 .


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