Dosage and Administration
The dosage of IR alfuzosin hydrochloride ranges from 2.5 mg p.o. thrice daily to a maximum of 10-12 mg/day. Frequent daily administration is required because of alfuzosin's short serum half-life.
There are two ER formulations of alfuzosin hydrochloride. One formulation can be prescribed as a 10-mg tablet once daily and the other as a 5-mg tablet twice daily. Neither formulation requires dosage titration. Both ER formulations produce less cardiovascular adverse effects than the IR formulation and other second-generation α-adrenergic antagonists. The adverse effect profile of these ER formulations is similar to placebo.
FDA is currently reviewing the once-a-day ER preparation for release onto the commercial market.
Common dosing regimens for various α1-adrenergic antagonists are summarized in Table 5 .
Am J Health Syst Pharm. 2003;60(14) © 2003 American Society of Health-System Pharmacists
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