Alfuzosin Hydrochloride for the Treatment of Benign Prostatic Hyperplasia

Mary Lee

Disclosures

Am J Health Syst Pharm. 2003;60(14) 

In This Article

Dosage and Administration

The dosage of IR alfuzosin hydrochloride ranges from 2.5 mg p.o. thrice daily to a maximum of 10-12 mg/day. Frequent daily administration is required because of alfuzosin's short serum half-life.

There are two ER formulations of alfuzosin hydrochloride. One formulation can be prescribed as a 10-mg tablet once daily and the other as a 5-mg tablet twice daily. Neither formulation requires dosage titration. Both ER formulations produce less cardiovascular adverse effects than the IR formulation and other second-generation α-adrenergic antagonists. The adverse effect profile of these ER formulations is similar to placebo.[84]

FDA is currently reviewing the once-a-day ER preparation for release onto the commercial market.

Common dosing regimens for various α1-adrenergic antagonists are summarized in Table 5 .

Comments

3090D553-9492-4563-8681-AD288FA52ACE
Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.

processing....