John Bartlett, MD


July 23, 2003

In This Article

Malaria Outcome: Effect of Age

Muhlberger N, Jelinek T, Behrens RH, et al. Age as a risk factor for severe manifestations and fatal outcome of Falciparum malaria in European patients: observations from TropNetEurop and SIMPID Surveillance Data. Clin Infect Dis. 2003;36:990-995. Abstract The authors report the results of a European network, TropNetEurop, and its sister organization in Germany, SIMPID, which are designed to detect emerging infections. The present report deals with Falciparum malaria reported to the networks for the period 1999 to 2002. The results are based on analysis of 3028 patients with imported Falciparum malaria with ages ranging from 10 to 81 years. There were 113 cases (9.6%) of severe malaria, including 37 (3.1%) with cerebral malaria. There were 17 (1.4%) deaths. The probability of developing severe disease increased by about 30% per decade of life. The authors conclude that Falciparum malaria is more serious in older patients, and their study also shows that networks with clinical surveillance are capable of generating high-quality data. The results of the study are summarized in Table 6 .


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