John Bartlett, MD


July 23, 2003

In This Article

Other Articles on Antimicrobial Agents or Drug Resistance

Critchley IA, Blosser-Middleton RS, Jones ME, Thornsberry C, Sahm DF, Karlowsky JA. Baseline study to determine in vitro activities of daptomycin against gram-positive pathogens isolated in the United States in 2000-2001. Antimicrob Agents Chemother. 2003;47:1689-1693. Abstract These authors report results of in vitro sensitivity testing of multiple antimicrobial agents against Streptococcus pneumoniae, other streptococci, Staphylococcus aureus, coagulase-negative staphylococci, and enterococci isolated in 50 US hospitals in 2000-2001. The strains were separated by sensitivity profiles. The results showed that 3 drugs were easily and highly effective against both antibiotic sensitive and multidrug-resistant strains: linezolid, daptomycin, and quinupristin-dalfopristin. The results are provided for the most resistant strains in Table 20 :

Comment: The table above provides sensitivity data for multiple drugs against the problem of gram-positive cocci. The data for daptomycin are given as the MIC-90 results because the National Committee for Clinical Laboratory Standards has not yet provided breakpoint data to define sensitivity. This drug is currently before the FDA and is expected to add substantially to our ability to deal effectively with these resistant organisms that have become so prevalent in hospital practice.


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