Efficacy of Betamethasone Valerate 0.1% Thermophobic Foam In Seborrhoeic Dermatitis of the Scalp: An Open-Label, Muticentre, Prospective Trial on 180 Patients

Massimo Milani, Sabino Antonio Di Molfetta, Raffaele Gramazio, Carmen Fiorella, Costantino Frisario, Ernesto Fuzio, Vincenzo Marzocca, Maria Zurilli, Giovanni Di Turi, Giovanni Felice


Curr Med Res Opin. 2003;19(4) 

In This Article


Seborrhoeic dermatitis is a common chronic inflammatory disease of the skin that affects 1-2% of the population.[7] The scalp is a common locality for these dermatoses. Topical antifungal compounds and topical corticosteroids are commonly used in seborrhoeic dermatitis. Mild corticosteroids are very effective in the treatment of this skin disease. However, there are few data regarding the clinical outcome following cessation of the topical treatment. Betamethasone valerate foam is a unique, low-residue, high bioavailability delivery form of betamethasone valerate.[5] It was developed to provide an increased efficacy with high patient acceptability and compliance. When applied to the scalp at body temperature, the foam rapidly breaks down (quick-break foam) and the active ingredient (betamethasone valerate) is deposited on the skin with little residue. Most of the vehicle components quickly evaporate and the active compound is rapidly adsorbed into the skin. An experimental study on a human skin model has shown that skin penetration of BVM is more than twice that of betamethasone valerate lotion.[4] Due to these characteristics, BVM is particularly suitable for the treatment of corticosteroid-responsive scalp dermatoses.

Randomised controlled trials have shown that BMV foam is more effective than corticosteroid lotions in the treatment of scalp dermatoses such as psoriasis and alopecia areata.[5] In our study we investigated not only the efficacy of BVM in the short-term treatment of seborrhoeic dermatitis, but we have also assessed whether clinical improvement was maintained in the medium term (2 months after stopping the treatment).


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