Efficacy of Betamethasone Valerate 0.1% Thermophobic Foam In Seborrhoeic Dermatitis of the Scalp: An Open-Label, Muticentre, Prospective Trial on 180 Patients

Massimo Milani, Sabino Antonio Di Molfetta, Raffaele Gramazio, Carmen Fiorella, Costantino Frisario, Ernesto Fuzio, Vincenzo Marzocca, Maria Zurilli, Giovanni Di Turi, Giovanni Felice

Disclosures

Curr Med Res Opin. 2003;19(4) 

In This Article

Discussion

Seborrhoeic dermatitis is a common chronic inflammatory disease of the skin that affects 1-2% of the population.[7] The scalp is a common locality for these dermatoses. Topical antifungal compounds and topical corticosteroids are commonly used in seborrhoeic dermatitis. Mild corticosteroids are very effective in the treatment of this skin disease. However, there are few data regarding the clinical outcome following cessation of the topical treatment. Betamethasone valerate foam is a unique, low-residue, high bioavailability delivery form of betamethasone valerate.[5] It was developed to provide an increased efficacy with high patient acceptability and compliance. When applied to the scalp at body temperature, the foam rapidly breaks down (quick-break foam) and the active ingredient (betamethasone valerate) is deposited on the skin with little residue. Most of the vehicle components quickly evaporate and the active compound is rapidly adsorbed into the skin. An experimental study on a human skin model has shown that skin penetration of BVM is more than twice that of betamethasone valerate lotion.[4] Due to these characteristics, BVM is particularly suitable for the treatment of corticosteroid-responsive scalp dermatoses.

Randomised controlled trials have shown that BMV foam is more effective than corticosteroid lotions in the treatment of scalp dermatoses such as psoriasis and alopecia areata.[5] In our study we investigated not only the efficacy of BVM in the short-term treatment of seborrhoeic dermatitis, but we have also assessed whether clinical improvement was maintained in the medium term (2 months after stopping the treatment).

Comments

3090D553-9492-4563-8681-AD288FA52ACE
Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.
Post as:

processing....