Management of the Infant With Gastroschisis: A Comprehensive Review of the Literature

Tracey Williams, MSN, RN, NNP, Rachel Butler, MSN, RN, NNP, Tara Sundem, MSN, RN, NNP


NAINR. 2003;3(2) 

In This Article

Embryological Basis

The embryologic development of gastroschisis involves maldevelopment of the abdominal wall. The abdominal wall is normally formed from the fusion of the cephalic, caudal, and right and left lateral folds of the mesoderm. These four folds usually meet and fuse in the center of the embryo to form the abdominal wall. Each of the mesodermal folds creates different portions of the abdominal wall. The cephalic fold forms the upper abdomen; the caudal fold forms the lower abdomen; and the lateral folds transform into both sides of the abdominal wall. As the folds are fusing, rotation occurs forming the umbilical ring. These folds are approaching the midline of the abdomen as the intestinal tract is beginning to form. By the 10th week of gestation, the anatomical positions of the abdominal wall contents should be complete. A defect of the abdominal wall can result if any of these four folds do not develop correctly.[18]


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