The etiology of gastroschisis is uncertain, but it has been reported to be of nongenetic origin. Four hypotheses for the etiology of the defect have been proposed. The first is that gastroschisis may result from a vascular disruption of the right lateral fold allowing the abdominal contents to herniate outside the abdominal cavity. The second is that the defect results from occlusion of the omphalomesenteric artery in utero. This occlusion may weaken the abdominal wall causing it to rupture. The third hypothesis is that premature atrophy or abnormal persistence of the right umbilical vein leads to mesenchymal damage and failure of the epidermis to differentiate. This damage or differentiation failure results in a defect of the abdominal wall. The fourth and last hypothesis is that a gastroschisis defect may be the end result of an intrauterine rupture of a small omphalocele with the absorption of the sac.
NAINR. 2003;3(2) © 2003 W.B. Saunders
Cite this: Management of the Infant With Gastroschisis: A Comprehensive Review of the Literature - Medscape - Jun 01, 2003.