Improvement in Hypertrophic Cardiomyopathy After Significant Weight Loss: Case Report

Gabriel I. Uwaifo, MD, Erica M. Fallon, BS, Karim A. Calis, PharMD, MPh, Bart Drinkard, PT, MSPT, CCS, Jennifer R. McDuffie, PhD, Jack A. Yanovski, MD, PhD

Disclosures

South Med J. 2003;96(6) 

In This Article

Limitations

Although the cardiac findings observed in our patient are compelling, it is important to be aware that the models used to estimate cardiac mass on the basis of the echocardiographic data are derived from mathematical geometric models that are limited, particularly in scenarios of asymmetric cardiac enlargement observed in FAHCM.[7] Model-based echocardiographic measures have been shown to underestimate significantly the prevalence of left ventricular hypertrophy, particularly among patients with hypertension.[30] Furthermore, the functional indices derived from color Doppler and echocardiographic studies are also potentially error-prone and not as accurate as radionuclide or right heart catheterization studies. Although the epidemiologic and echocardiographic findings were typical and virtually diagnostic of FAHCM, the absence of a significant family history of sudden cardiac death and the absence of a definitive genetic diagnosis does raise the possibility of the findings' being entirely attributable to obesity rather than to a primary familial cardiomyopathy.

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