Epidermodysplasia Verruciformis

Joshua E. Lane, MD, Paul H. Bowman, MD, David J. Cohen, MD


South Med J. 2003;96(6) 

In This Article

Abstract and Introduction

Epidermodysplasia verruciformis is an uncommon cutaneous entity characterized by persistent human papillomavirus infection. A defect in cell-mediated immunity is the suggested causative factor. Numerous specific human papillomavirus types have been detected in this disease. Multiple nonmelanoma skin cancers are commonly seen in such patients; thus, early diagnosis is beneficial.

Epidermodysplasia verruciformis (EV) is a rare cutaneous disorder characterized by persistent human papillomavirus (HPV) infection. This disease results from a genetically determined defect in cutaneous immunity that leaves afflicted individuals susceptible to persistent HPV infection. In addition, there is an association with squamous cell carcinoma of the skin. Thus, early diagnosis and routine monitoring is essential for these patients. We present a 45-year-old male with epidermodysplasia verruciformis and review the literature.


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