Efficacy and Safety of Stabilised Hydrogen Peroxide Cream (Crystacide) in Mild-to-Moderate Acne Vulgaris: A Randomised, Controlled Trial Versus Benzoyl Peroxide Gel

Massimo Milani, Andrea Bigardi, Marco Zavattarelli

Disclosures

Curr Med Res Opin. 2003;19(2) 

In This Article

Results

Patients demographic characteristics at baseline are summarised in Table 1 . TL, NIL, and IL were assessed by an investigator, unaware of treatment allocation, at baseline, and week 8. The TS was assessed at week 4 and 8. At baseline, the two groups were well matched for the main clinical and demographic characteristics. All randomised patients concluded the trial. At week 0, TL, NL and IL were: 35 ± 8, 20 ± 6 and 16 ± 7 in the HPS group and 32 ± 9, 24 ± 8 and 18 ± 7 in the BP group, respectively. At week 8, HPS reduced TL to 16 ± 7; NL to 9 ± 3 and IL to 7 ± 3 (p < 0.001); BP reduced TL, NL and IL to 14 ± 9; 7 ± 5 and 7 ± 3, respectively (p < 0.001) (Figure 1). No significant differences were found between the two treatments. In comparison with baseline, the percentage reduction of TL was 55% and 57% for HPS and BP respectively (p = n.s). The percentage reduction of IL was 58% for HPS and 61% for the BP groups, respectively (p = n.s.) At the end of the study TS was 2.9 ± 0.2 in the HPS group and 2.4 ± 0.8 in the BP group (p < 0.025). Two patients in the HPS group (6%) and seven patients (23%) in the BP group suffered from mild-to-moderate local erythema.

Total (TL) and inflammatory (IL) acneic lesion count (mean ± SD) at baseline and at week 8. HPS, hydrogen peroxide cream; BP, benzoyl peroxide.*p < 0.001 vs baseline values

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