Jane S. Ricciuti, RPh, MS

Disclosures

April 22, 2003

In This Article

Cardiovascular Agents

Coreg
(carvedilol)

Manufacturer: GlaxoSmithKline

Drug Approval Classification: Supplemental New Drug Application (Approval Date: 03/28/03)

New Indication: Coreg (carvedilol) is indicated for the treatment of patients with left ventricular dysfunction following myocardial infarction.

Coreg is also indicated for the treatment of essential hypertension.

Clinical Summary: CAPRICORN (CArvedilol Post InfaRction SurvIval COntRol in Left Ventricular DysfunctioN) trial -- a multinational, multicenter, randomized, double-blind, parallel group study in patients with left ventricular systolic dysfunction following a recent acute myocardial infarction -- evaluated the efficacy of carvedilol. A total of 1949 patients were randomized to carvedilol 6.25 mg twice daily or placebo and followed for a mean of 15 months. Ninety-eight percent of patients on study took an angiotensin II converting enzyme inhibitor. The risk of death was 23% lower for patients on carvedilol compared with placebo.

Coreg (carvedilol) Letter

Coreg (carvedilol)

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