Nancy L. Stitt, RN, BSN


April 03, 2003

Epidemiology of Posttransplant Infection

Specific etiologies, predisposing factors, frequency, and type of posttransplant infection differ and vary depending on the organ transplanted and the individual transplant center. However, the major factor responsible for posttransplant infection in all transplanted organs is the use of immunosuppression, which alters normal protective responses. A predisposing factor to infection in the transplant recipient is the preoperative condition of the patient (ie, presence of end-stage organ disease [uremia, cirrhosis, cardiomyopathy], nutritional status, splenic function). Nosocomial factors that cause shifts in microbial flora include surgical and/or invasive procedures, the hospital and critical care environments, the presence of multiresistant hospital organisms, administration of antibiotics, and immunosuppression.


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