Nancy L. Stitt, RN, BSN


April 03, 2003


The introduction of newer immunosuppressive agents has led to changes in the spectrum of infection occurring after SOT. To avoid delays in diagnosis and institution of appropriate antimicrobial therapy, clinicians should be aware of the blunted inflammatory response in transplant recipients. Such patients may have overwhelming sepsis, and yet fail to exhibit any signs or symptoms suggestive of an ongoing infection. Viruses are of particular importance in SOT because they are unequivocally implicated in the etiology and pathogenesis of the 3 major causes of graft loss: transplant infection, atherosclerosis, and malignancy. An increased understanding of these viruses and the infections they cause may lead to improved treatment and prevention, resulting in improved graft and patient survival.


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