The Clinical Application of CRP Testing in Infants With Suspected Sepsis
When used appropriately, serial CRP levels are a useful clinical tool. The following evidence-based guidelines are offered for the use of CRP in the evaluation and management of infants with suspected sepsis:
Carefully review the maternal and infant's history and physical and clinical course to assess for confounding factors that could increase CRP levels.
Use serial CRP levels in conjunction with other established sepsis workup tests, including WBC count with differential and blood culture.
CRP testing should be used only in term and near-term infants.
Begin drawing quantitative CRP measurements 24 hours after the onset of signs and symptoms of infection. Repeat the level 24 hours later to capture the maximal rise.
Obtain at least 2 normal CRP levels (≤10 mg/L) 24 hours apart to identify infants unlikely to be infected.
Consider discontinuing antibiotics at 48 hr if at least 2 CRP levels are normal.
This article was written while completing an NNP master's program at Rush University College of Nursing, Chicago, IL. The author thanks the former NNP Program Director at Rush University, Angela Carlson, RNC, ND, NNP, for her assistance and support in writing this article.Reprint Address
Address reprint requests to Joan M. Hengst, RNC, MSN, ARNP, Blank Children's Hospital, 1200 Pleasant St, Des Moines, IA 50309. E-mail: firstname.lastname@example.org
Adv Neonatal Care. 2003;3(1) © 2003 W.B. Saunders
Cite this: The Role of C-Reactive Protein in the Evaluation and Management of Infants With Suspected Sepsis - Medscape - Feb 01, 2003.