Characteristics and Outcomes of Patients With Goodpasture's Syndrome

Mrugeshkumar K. Shah, MD, MPH, MS, Stephanie Y. Hugghins, MD

South Med J. 2002;95(12)

Materials and Methods

We searched MEDLINE using the keywords Goodpasture's syndrome, Goodpasture's, case report, and antiglomerular basement membrane disease in various combinations. Articles were reviewed to identify validity of Goodpasture's syndrome. To ensure all the reported cases were found, the references in the articles acquired that were not found in the MEDLINE search were further investigated. After the review process, a total of 85 cases were identified in which Goodpasture's syndrome was present. The information regarding these cases is summarized in Table 1 .^{[5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61]}

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Table 1. Case Reports of Goodpasture's Syndrome Between 1993 and 2000
Reference, Year	Race Sex	Age	Pulmonary Hemorrhage	Type GN	Anti-GBM (Serum)	Risk Factors	Treatment	Outcome
5, 1993	x, M	47	x	x/linear, IgG, IgA	Yes	Tobacco	C, P	x
6, 1993	x, M	59	x	Cr/linear, IgG	Yes	x	S,C,P,HD	HD
6, 1993	x, F	17	No	Cr/linear, IgG	Yes	x	S,C	x
7, 1993	W, M	25	x	x	x	x	S,P	Transplantation
8, 1993	W, F	23	No	Cr/linear, IgG	No	URI, tobacco	S,P,Az	Recovered
9, 1993	x, M	40	Yes	x	Yes	x	S,C,P	HD
9, 1993	x, M	58	Yes	Cr/x	Yes	x	S,C,P	HD
10, 1993	W, M	24	Probably	Normal/linear, IgG, C3	No	HC	S,C,P	Recovered
11, 1993	x, M	26	Yes	RP/linear, IgG, C3	Yes	URI, HC	S,C,P	Recovered
12, 1993	x, M	75	x	x/linear, IgG	Yes	x	S,P	Died
13, 1993	x, F	13	Yes	Cr/linear, IgG, C3	Yes	x	S	Recovered
13, 1993	x, F	17	Yes	Cr/linear, IgG, C3	Yes	URI, tobacco	S,C	Died
14, 1993	x, F	19	Yes	x	Yes	Tobacco, HC	x	HD
15, 1994	W, M	31	Yes	Cr/linear, IgG	Yes	Tobacco, possible HC	S,C,Az	Awaiting transplant
16, 1994	B, M	60	No	Cr/IgG, C3	No	None	S,C,P	Died
16, 1994	B, M	56	Yes	x	Yes	Tobacco	S,C,P	HD, awaiting transplant
16, 1994	B, M	29	Yes	x	Yes	URI	S,C,P	Died
16, 1994	W, M	45	Yes	Cr/IgG, IgA, IgM, C3	Yes	Tobacco, possible HC	S,C,P	HD
16, 1994	W, M	60	Yes	PM/linear	Yes	Possible HC	x	Normal renal function
16, 1994	W, M	21	Yes	x	Yes	Tobacco, possible HC	S,C,P	Died (PH)
16, 1994	B, F	26	Yes	Me/linear, IgG, C3	No	URI, tobacco	S,C,P	Recovered
16, 1994	W, F	59	Yes	Cr/linear, IgG, IgM	Yes	URI, tobacco, possible HC	S,C,P	Recovered
16, 1994	W, F	65	Yes	Cr/linear, IgG	Yes	None	S,C,P	Died
17, 1994	x, M	x	Yes	x	Yes	x	S,C,P	Transplantation
18, 1994	x, F	40	Yes	x	Yes	Tobacco	x	Transplantation
19, 1994	W, x	30	x	x	x	x	x	HD
20, 1994	x, M	21	No	RP/linear, IgG	Yes	x	Az, HD	x
21, 1994	x, F	72	x	Cr/x	Yes	x	HD	HD
22, 1995	x, F	67	No	Cr/linear, IgG	Yes	x	HD	HD
22, 1995	x, M	75	Yes	x	Yes	Tobacco	HD	HD
22, 1995	x, M	79	Yes	x	Yes	None	HD, S	Died
22, 1995	x, F	70	No	x	Yes	None	HD	HD
22, 1995	x, F	9	Yes	x	Yes	None	HD, S	HD
22, 1995	x, M	34	No	x	Yes	None	HD	HD
22, 1995	x, M	23	No	x	Yes	Tobacco	HD, S	HD
22, 1995	x, F	52	Yes	x	Yes	None	HD, S	HD
22, 1995	x, F	64	Yes	x	Yes	None	HD, S	HD
22, 1995	x, F	77	Yes	x	Yes	None	HD, S	Died
22, 1995	x, F	27	No	x	Yes	None	HD	HD
22, 1995	x, M	31	No	x	Yes	Tobacco	HD	HD
22, 1995	x, M	77	No	x	Yes	Tobacco	HD	HD
22, 1995	x, M	25	Yes	x	Yes	Tobacco	S	HD
22, 1995	x, F	15	No	x	Yes	None	HD, S	HD
23, 1995	W, M	24	Yes	x/IgG,C3	Yes	x	S,C,P	x
25, 1995	x, F	70	No	Cr/linear, IgG, C3	Yes	None	S, P, HD	x
26, 1995	x, F	72	x	Cr/linear, IgG	Yes	x	S,C	HD
27, 1995	x, M	24	Yes	C/x	Yes	x	S,C,P	x
28, 1995	B, M	57	Yes	Cr/IgG, C3	Yes	x	S,C,P	HD
29, 1996	W, M	72	Yes	Cr/x	Yes	Tobacco history	S,C,P	Died
30, 1996	x, M	65	No	x/linear	Yes	None	S	x
31, 1996	W, M	59	Yes	FS, Cr/linear IgG	Yes	Tobacco history, possible HC	S,C	x
32, 1996	x, M	11	Yes	x	x	x	x	HD
33, 1996	W, M	20	Yes	Cr/IgG	Yes	Tobacco	S,C,P	Transplantation
34, 1996	x, M	22	Yes	x	Yes	URI, tobacco, HC	S,C,P	Recovered
35, 1996	W, M	68	No	Cr/linear, IgG	Yes	x	S,C,P	Died (CVA)
36, 1996	W, F	49	Yes	x	Yes	Tobacco history	S,P,Az	HD
37, 1996	x, F	22	Yes	x	x	x	S, HD	Transplantation
38, 1997	W, F	21	Yes	Cr/linear, IgG	Yes	URI, possible tobacco	HD	x
39, 1997	W, F	53	No	Cr, FS/linear, IgG	Yes	x	S,C,P,Az,HD	Recovered
40, 1997	x, M	32	Yes	x/linear, IgG	Yes	Tobacco	x	HD
41, 1997	x, F	68	x	Cr/linear, IgG	Yes	Tobacco	x	Died (CVA)
42, 1997	x, M	70	Yes	Cr/linear, IgG	No	Tobacco	S,C,P,HD	Died
43, 1997	x, F	19	Yes	Normal/linear, IgG	Yes	Tobacco	S,C	Recovered
44, 1998	W, M	57	No	Cr/IgG	Yes	None	S,C,P	Recovered
45, 1998	W, M	49	Yes	x/IgG	Yes	URI	S,C,P	HD
46, 1998	x, F	44	Yes	Cr/linear	Yes	x	S,P,HD	Died (RF)
47, 1998	x, F	73	Yes	x/linear IgG	Yes	x	S	Died (RF)
48, 1998	x, M	18	Yes	Cr/linear	Yes	x	S,C,P	Transplantation
49, 1998	x, F	78	Yes	Cr/linear, IgG, C3	Yes	x	S,C,P	PD
49, 1998	x, M	65	x	Cr/IgG, C3	Yes	x	S,C,P	HD
50, 1998	W, M	18	Yes	Cr/linear, IgG, C3	Yes	URI, tobacco	S,P,HD	Recovered
51, 1998	x, F	71	Yes	Cr/linear, IgG, C3	Yes	x	S,C,P	Died
52, 1998	W, F	20	Yes	Cr/linear, IgG	Yes	x	S,C,P	Recovered
52, 1998	W, F	63	x	Cr/linear, IgG	Yes	x	S,C,P	Transplantation
53, 1999	x, M	54	Yes	x/IgA	Yes (IgA)	Possible HC	S,C,P	Recovered
54, 1999	W, M	21	Yes	Normal/linear, IgG, C3	No	URI, tobacco	S,C	Recovered
55, 1999	x, M	67	x	Cr/linear, IgA	Yes (IgA)	Tobacco	S,C	Died
56, 1999	x, M	35	Yes	Cr/linear, IgG, C3	Yes	Tobacco	S,C	HD, awaiting transplant
57, 1999	x, M	39	Yes	Cr/linear, IgG, C3	Yes	URI, possible HC	S, P, Az	Transplantation
58, 1999	W, M	23	Yes	FS/linear	Yes	Tobacco	S,P	x
59, 2000	x, M	19	Yes	Cr/linear, IgG	Yes	None	S,C,P,HD,MY	Transplantation
60, 2000	x, M	20	Yes	GS,Cr/linear, IgG	Yes	x	S,C,P,HD	HD
61, 2000	x, F	18	Yes	Cr/linear, IgG	No	HLA-DR2	S,C,HD,Im	Recovered
61, 2000	x, F	26	Yes	Cr/linear, IgG	Yes	HLA-DR2	S, Im	Recovered

Table 1. Case Reports of Goodpasture's Syndrome Between 1993 and 2000
Reference, Year	Race Sex	Age	Pulmonary Hemorrhage	Type GN	Anti-GBM (Serum)	Risk Factors	Treatment	Outcome
5, 1993	x, M	47	x	x/linear, IgG, IgA	Yes	Tobacco	C, P	x
6, 1993	x, M	59	x	Cr/linear, IgG	Yes	x	S,C,P,HD	HD
6, 1993	x, F	17	No	Cr/linear, IgG	Yes	x	S,C	x
7, 1993	W, M	25	x	x	x	x	S,P	Transplantation
8, 1993	W, F	23	No	Cr/linear, IgG	No	URI, tobacco	S,P,Az	Recovered
9, 1993	x, M	40	Yes	x	Yes	x	S,C,P	HD
9, 1993	x, M	58	Yes	Cr/x	Yes	x	S,C,P	HD
10, 1993	W, M	24	Probably	Normal/linear, IgG, C3	No	HC	S,C,P	Recovered
11, 1993	x, M	26	Yes	RP/linear, IgG, C3	Yes	URI, HC	S,C,P	Recovered
12, 1993	x, M	75	x	x/linear, IgG	Yes	x	S,P	Died
13, 1993	x, F	13	Yes	Cr/linear, IgG, C3	Yes	x	S	Recovered
13, 1993	x, F	17	Yes	Cr/linear, IgG, C3	Yes	URI, tobacco	S,C	Died
14, 1993	x, F	19	Yes	x	Yes	Tobacco, HC	x	HD
15, 1994	W, M	31	Yes	Cr/linear, IgG	Yes	Tobacco, possible HC	S,C,Az	Awaiting transplant
16, 1994	B, M	60	No	Cr/IgG, C3	No	None	S,C,P	Died
16, 1994	B, M	56	Yes	x	Yes	Tobacco	S,C,P	HD, awaiting transplant
16, 1994	B, M	29	Yes	x	Yes	URI	S,C,P	Died
16, 1994	W, M	45	Yes	Cr/IgG, IgA, IgM, C3	Yes	Tobacco, possible HC	S,C,P	HD
16, 1994	W, M	60	Yes	PM/linear	Yes	Possible HC	x	Normal renal function
16, 1994	W, M	21	Yes	x	Yes	Tobacco, possible HC	S,C,P	Died (PH)
16, 1994	B, F	26	Yes	Me/linear, IgG, C3	No	URI, tobacco	S,C,P	Recovered
16, 1994	W, F	59	Yes	Cr/linear, IgG, IgM	Yes	URI, tobacco, possible HC	S,C,P	Recovered
16, 1994	W, F	65	Yes	Cr/linear, IgG	Yes	None	S,C,P	Died
17, 1994	x, M	x	Yes	x	Yes	x	S,C,P	Transplantation
18, 1994	x, F	40	Yes	x	Yes	Tobacco	x	Transplantation
19, 1994	W, x	30	x	x	x	x	x	HD
20, 1994	x, M	21	No	RP/linear, IgG	Yes	x	Az, HD	x
21, 1994	x, F	72	x	Cr/x	Yes	x	HD	HD
22, 1995	x, F	67	No	Cr/linear, IgG	Yes	x	HD	HD
22, 1995	x, M	75	Yes	x	Yes	Tobacco	HD	HD
22, 1995	x, M	79	Yes	x	Yes	None	HD, S	Died
22, 1995	x, F	70	No	x	Yes	None	HD	HD
22, 1995	x, F	9	Yes	x	Yes	None	HD, S	HD
22, 1995	x, M	34	No	x	Yes	None	HD	HD
22, 1995	x, M	23	No	x	Yes	Tobacco	HD, S	HD
22, 1995	x, F	52	Yes	x	Yes	None	HD, S	HD
22, 1995	x, F	64	Yes	x	Yes	None	HD, S	HD
22, 1995	x, F	77	Yes	x	Yes	None	HD, S	Died
22, 1995	x, F	27	No	x	Yes	None	HD	HD
22, 1995	x, M	31	No	x	Yes	Tobacco	HD	HD
22, 1995	x, M	77	No	x	Yes	Tobacco	HD	HD
22, 1995	x, M	25	Yes	x	Yes	Tobacco	S	HD
22, 1995	x, F	15	No	x	Yes	None	HD, S	HD
23, 1995	W, M	24	Yes	x/IgG,C3	Yes	x	S,C,P	x
25, 1995	x, F	70	No	Cr/linear, IgG, C3	Yes	None	S, P, HD	x
26, 1995	x, F	72	x	Cr/linear, IgG	Yes	x	S,C	HD
27, 1995	x, M	24	Yes	C/x	Yes	x	S,C,P	x
28, 1995	B, M	57	Yes	Cr/IgG, C3	Yes	x	S,C,P	HD
29, 1996	W, M	72	Yes	Cr/x	Yes	Tobacco history	S,C,P	Died
30, 1996	x, M	65	No	x/linear	Yes	None	S	x
31, 1996	W, M	59	Yes	FS, Cr/linear IgG	Yes	Tobacco history, possible HC	S,C	x
32, 1996	x, M	11	Yes	x	x	x	x	HD
33, 1996	W, M	20	Yes	Cr/IgG	Yes	Tobacco	S,C,P	Transplantation
34, 1996	x, M	22	Yes	x	Yes	URI, tobacco, HC	S,C,P	Recovered
35, 1996	W, M	68	No	Cr/linear, IgG	Yes	x	S,C,P	Died (CVA)
36, 1996	W, F	49	Yes	x	Yes	Tobacco history	S,P,Az	HD
37, 1996	x, F	22	Yes	x	x	x	S, HD	Transplantation
38, 1997	W, F	21	Yes	Cr/linear, IgG	Yes	URI, possible tobacco	HD	x
39, 1997	W, F	53	No	Cr, FS/linear, IgG	Yes	x	S,C,P,Az,HD	Recovered
40, 1997	x, M	32	Yes	x/linear, IgG	Yes	Tobacco	x	HD
41, 1997	x, F	68	x	Cr/linear, IgG	Yes	Tobacco	x	Died (CVA)
42, 1997	x, M	70	Yes	Cr/linear, IgG	No	Tobacco	S,C,P,HD	Died
43, 1997	x, F	19	Yes	Normal/linear, IgG	Yes	Tobacco	S,C	Recovered
44, 1998	W, M	57	No	Cr/IgG	Yes	None	S,C,P	Recovered
45, 1998	W, M	49	Yes	x/IgG	Yes	URI	S,C,P	HD
46, 1998	x, F	44	Yes	Cr/linear	Yes	x	S,P,HD	Died (RF)
47, 1998	x, F	73	Yes	x/linear IgG	Yes	x	S	Died (RF)
48, 1998	x, M	18	Yes	Cr/linear	Yes	x	S,C,P	Transplantation
49, 1998	x, F	78	Yes	Cr/linear, IgG, C3	Yes	x	S,C,P	PD
49, 1998	x, M	65	x	Cr/IgG, C3	Yes	x	S,C,P	HD
50, 1998	W, M	18	Yes	Cr/linear, IgG, C3	Yes	URI, tobacco	S,P,HD	Recovered
51, 1998	x, F	71	Yes	Cr/linear, IgG, C3	Yes	x	S,C,P	Died
52, 1998	W, F	20	Yes	Cr/linear, IgG	Yes	x	S,C,P	Recovered
52, 1998	W, F	63	x	Cr/linear, IgG	Yes	x	S,C,P	Transplantation
53, 1999	x, M	54	Yes	x/IgA	Yes (IgA)	Possible HC	S,C,P	Recovered
54, 1999	W, M	21	Yes	Normal/linear, IgG, C3	No	URI, tobacco	S,C	Recovered
55, 1999	x, M	67	x	Cr/linear, IgA	Yes (IgA)	Tobacco	S,C	Died
56, 1999	x, M	35	Yes	Cr/linear, IgG, C3	Yes	Tobacco	S,C	HD, awaiting transplant
57, 1999	x, M	39	Yes	Cr/linear, IgG, C3	Yes	URI, possible HC	S, P, Az	Transplantation
58, 1999	W, M	23	Yes	FS/linear	Yes	Tobacco	S,P	x
59, 2000	x, M	19	Yes	Cr/linear, IgG	Yes	None	S,C,P,HD,MY	Transplantation
60, 2000	x, M	20	Yes	GS,Cr/linear, IgG	Yes	x	S,C,P,HD	HD
61, 2000	x, F	18	Yes	Cr/linear, IgG	No	HLA-DR2	S,C,HD,Im	Recovered
61, 2000	x, F	26	Yes	Cr/linear, IgG	Yes	HLA-DR2	S, Im	Recovered

Table 2. Signs and Symptoms in Patients With Goodpasture's Syndrome
	No. of Patients
Symptoms
Hemoptysis	35/54 (65%)
Cough	15/54 (28%)
Shortness of breath	15/54 (28%)
Fever	15/54 (28%)
Dyspnea on exertion	14/54 (26%)
Nausea/vomiting	11/54 (20%)
Chest pain	10/54 (19%)
Lower extermity edema	9/54 (17%)
Oliguria/decreased urine output	9/54 (17%)
Fatigue	8/54 (15%)
Myalgia	7/54 (13%)
Malaise	7/54 (13%)
Weight loss	5/54 (9%)
Hematuria	4/54 (7%)
Weakness	4/54 (7%)
Chills	3/54 (6%)
Orthopnea	2/54 (4%)
Anemia	2/54 (4%)
Signs
Crackles	16/35 (46%)
Lower extermity edema	12/35 (34%)
Normal	10/35 (29%)
Tachycardia	9/35 (26%)
Tachypnea	9/35 (26%)
Rhonchi	4/35 (11%)
Fever	2/35 (6%)
Murmur	2/35 (6%)
Jugular venous distention	1/35 (3%)
Pallor	1/35 (3%)
Visual changes	1/35 (3%)
Hemoptysis	1/35 (3%)

Table 1. Case Reports of Goodpasture's Syndrome Between 1993 and 2000
Reference, Year	Race Sex	Age	Pulmonary Hemorrhage	Type GN	Anti-GBM (Serum)	Risk Factors	Treatment	Outcome
5, 1993	x, M	47	x	x/linear, IgG, IgA	Yes	Tobacco	C, P	x
6, 1993	x, M	59	x	Cr/linear, IgG	Yes	x	S,C,P,HD	HD
6, 1993	x, F	17	No	Cr/linear, IgG	Yes	x	S,C	x
7, 1993	W, M	25	x	x	x	x	S,P	Transplantation
8, 1993	W, F	23	No	Cr/linear, IgG	No	URI, tobacco	S,P,Az	Recovered
9, 1993	x, M	40	Yes	x	Yes	x	S,C,P	HD
9, 1993	x, M	58	Yes	Cr/x	Yes	x	S,C,P	HD
10, 1993	W, M	24	Probably	Normal/linear, IgG, C3	No	HC	S,C,P	Recovered
11, 1993	x, M	26	Yes	RP/linear, IgG, C3	Yes	URI, HC	S,C,P	Recovered
12, 1993	x, M	75	x	x/linear, IgG	Yes	x	S,P	Died
13, 1993	x, F	13	Yes	Cr/linear, IgG, C3	Yes	x	S	Recovered
13, 1993	x, F	17	Yes	Cr/linear, IgG, C3	Yes	URI, tobacco	S,C	Died
14, 1993	x, F	19	Yes	x	Yes	Tobacco, HC	x	HD
15, 1994	W, M	31	Yes	Cr/linear, IgG	Yes	Tobacco, possible HC	S,C,Az	Awaiting transplant
16, 1994	B, M	60	No	Cr/IgG, C3	No	None	S,C,P	Died
16, 1994	B, M	56	Yes	x	Yes	Tobacco	S,C,P	HD, awaiting transplant
16, 1994	B, M	29	Yes	x	Yes	URI	S,C,P	Died
16, 1994	W, M	45	Yes	Cr/IgG, IgA, IgM, C3	Yes	Tobacco, possible HC	S,C,P	HD
16, 1994	W, M	60	Yes	PM/linear	Yes	Possible HC	x	Normal renal function
16, 1994	W, M	21	Yes	x	Yes	Tobacco, possible HC	S,C,P	Died (PH)
16, 1994	B, F	26	Yes	Me/linear, IgG, C3	No	URI, tobacco	S,C,P	Recovered
16, 1994	W, F	59	Yes	Cr/linear, IgG, IgM	Yes	URI, tobacco, possible HC	S,C,P	Recovered
16, 1994	W, F	65	Yes	Cr/linear, IgG	Yes	None	S,C,P	Died
17, 1994	x, M	x	Yes	x	Yes	x	S,C,P	Transplantation
18, 1994	x, F	40	Yes	x	Yes	Tobacco	x	Transplantation
19, 1994	W, x	30	x	x	x	x	x	HD
20, 1994	x, M	21	No	RP/linear, IgG	Yes	x	Az, HD	x
21, 1994	x, F	72	x	Cr/x	Yes	x	HD	HD
22, 1995	x, F	67	No	Cr/linear, IgG	Yes	x	HD	HD
22, 1995	x, M	75	Yes	x	Yes	Tobacco	HD	HD
22, 1995	x, M	79	Yes	x	Yes	None	HD, S	Died
22, 1995	x, F	70	No	x	Yes	None	HD	HD
22, 1995	x, F	9	Yes	x	Yes	None	HD, S	HD
22, 1995	x, M	34	No	x	Yes	None	HD	HD
22, 1995	x, M	23	No	x	Yes	Tobacco	HD, S	HD
22, 1995	x, F	52	Yes	x	Yes	None	HD, S	HD
22, 1995	x, F	64	Yes	x	Yes	None	HD, S	HD
22, 1995	x, F	77	Yes	x	Yes	None	HD, S	Died
22, 1995	x, F	27	No	x	Yes	None	HD	HD
22, 1995	x, M	31	No	x	Yes	Tobacco	HD	HD
22, 1995	x, M	77	No	x	Yes	Tobacco	HD	HD
22, 1995	x, M	25	Yes	x	Yes	Tobacco	S	HD
22, 1995	x, F	15	No	x	Yes	None	HD, S	HD
23, 1995	W, M	24	Yes	x/IgG,C3	Yes	x	S,C,P	x
25, 1995	x, F	70	No	Cr/linear, IgG, C3	Yes	None	S, P, HD	x
26, 1995	x, F	72	x	Cr/linear, IgG	Yes	x	S,C	HD
27, 1995	x, M	24	Yes	C/x	Yes	x	S,C,P	x
28, 1995	B, M	57	Yes	Cr/IgG, C3	Yes	x	S,C,P	HD
29, 1996	W, M	72	Yes	Cr/x	Yes	Tobacco history	S,C,P	Died
30, 1996	x, M	65	No	x/linear	Yes	None	S	x
31, 1996	W, M	59	Yes	FS, Cr/linear IgG	Yes	Tobacco history, possible HC	S,C	x
32, 1996	x, M	11	Yes	x	x	x	x	HD
33, 1996	W, M	20	Yes	Cr/IgG	Yes	Tobacco	S,C,P	Transplantation
34, 1996	x, M	22	Yes	x	Yes	URI, tobacco, HC	S,C,P	Recovered
35, 1996	W, M	68	No	Cr/linear, IgG	Yes	x	S,C,P	Died (CVA)
36, 1996	W, F	49	Yes	x	Yes	Tobacco history	S,P,Az	HD
37, 1996	x, F	22	Yes	x	x	x	S, HD	Transplantation
38, 1997	W, F	21	Yes	Cr/linear, IgG	Yes	URI, possible tobacco	HD	x
39, 1997	W, F	53	No	Cr, FS/linear, IgG	Yes	x	S,C,P,Az,HD	Recovered
40, 1997	x, M	32	Yes	x/linear, IgG	Yes	Tobacco	x	HD
41, 1997	x, F	68	x	Cr/linear, IgG	Yes	Tobacco	x	Died (CVA)
42, 1997	x, M	70	Yes	Cr/linear, IgG	No	Tobacco	S,C,P,HD	Died
43, 1997	x, F	19	Yes	Normal/linear, IgG	Yes	Tobacco	S,C	Recovered
44, 1998	W, M	57	No	Cr/IgG	Yes	None	S,C,P	Recovered
45, 1998	W, M	49	Yes	x/IgG	Yes	URI	S,C,P	HD
46, 1998	x, F	44	Yes	Cr/linear	Yes	x	S,P,HD	Died (RF)
47, 1998	x, F	73	Yes	x/linear IgG	Yes	x	S	Died (RF)
48, 1998	x, M	18	Yes	Cr/linear	Yes	x	S,C,P	Transplantation
49, 1998	x, F	78	Yes	Cr/linear, IgG, C3	Yes	x	S,C,P	PD
49, 1998	x, M	65	x	Cr/IgG, C3	Yes	x	S,C,P	HD
50, 1998	W, M	18	Yes	Cr/linear, IgG, C3	Yes	URI, tobacco	S,P,HD	Recovered
51, 1998	x, F	71	Yes	Cr/linear, IgG, C3	Yes	x	S,C,P	Died
52, 1998	W, F	20	Yes	Cr/linear, IgG	Yes	x	S,C,P	Recovered
52, 1998	W, F	63	x	Cr/linear, IgG	Yes	x	S,C,P	Transplantation
53, 1999	x, M	54	Yes	x/IgA	Yes (IgA)	Possible HC	S,C,P	Recovered
54, 1999	W, M	21	Yes	Normal/linear, IgG, C3	No	URI, tobacco	S,C	Recovered
55, 1999	x, M	67	x	Cr/linear, IgA	Yes (IgA)	Tobacco	S,C	Died
56, 1999	x, M	35	Yes	Cr/linear, IgG, C3	Yes	Tobacco	S,C	HD, awaiting transplant
57, 1999	x, M	39	Yes	Cr/linear, IgG, C3	Yes	URI, possible HC	S, P, Az	Transplantation
58, 1999	W, M	23	Yes	FS/linear	Yes	Tobacco	S,P	x
59, 2000	x, M	19	Yes	Cr/linear, IgG	Yes	None	S,C,P,HD,MY	Transplantation
60, 2000	x, M	20	Yes	GS,Cr/linear, IgG	Yes	x	S,C,P,HD	HD
61, 2000	x, F	18	Yes	Cr/linear, IgG	No	HLA-DR2	S,C,HD,Im	Recovered
61, 2000	x, F	26	Yes	Cr/linear, IgG	Yes	HLA-DR2	S, Im	Recovered

Table 2. Signs and Symptoms in Patients With Goodpasture's Syndrome
	No. of Patients
Symptoms
Hemoptysis	35/54 (65%)
Cough	15/54 (28%)
Shortness of breath	15/54 (28%)
Fever	15/54 (28%)
Dyspnea on exertion	14/54 (26%)
Nausea/vomiting	11/54 (20%)
Chest pain	10/54 (19%)
Lower extermity edema	9/54 (17%)
Oliguria/decreased urine output	9/54 (17%)
Fatigue	8/54 (15%)
Myalgia	7/54 (13%)
Malaise	7/54 (13%)
Weight loss	5/54 (9%)
Hematuria	4/54 (7%)
Weakness	4/54 (7%)
Chills	3/54 (6%)
Orthopnea	2/54 (4%)
Anemia	2/54 (4%)
Signs
Crackles	16/35 (46%)
Lower extermity edema	12/35 (34%)
Normal	10/35 (29%)
Tachycardia	9/35 (26%)
Tachypnea	9/35 (26%)
Rhonchi	4/35 (11%)
Fever	2/35 (6%)
Murmur	2/35 (6%)
Jugular venous distention	1/35 (3%)
Pallor	1/35 (3%)
Visual changes	1/35 (3%)
Hemoptysis	1/35 (3%)

Table 1. Case Reports of Goodpasture's Syndrome Between 1993 and 2000
Reference, Year	Race Sex	Age	Pulmonary Hemorrhage	Type GN	Anti-GBM (Serum)	Risk Factors	Treatment	Outcome
5, 1993	x, M	47	x	x/linear, IgG, IgA	Yes	Tobacco	C, P	x
6, 1993	x, M	59	x	Cr/linear, IgG	Yes	x	S,C,P,HD	HD
6, 1993	x, F	17	No	Cr/linear, IgG	Yes	x	S,C	x
7, 1993	W, M	25	x	x	x	x	S,P	Transplantation
8, 1993	W, F	23	No	Cr/linear, IgG	No	URI, tobacco	S,P,Az	Recovered
9, 1993	x, M	40	Yes	x	Yes	x	S,C,P	HD
9, 1993	x, M	58	Yes	Cr/x	Yes	x	S,C,P	HD
10, 1993	W, M	24	Probably	Normal/linear, IgG, C3	No	HC	S,C,P	Recovered
11, 1993	x, M	26	Yes	RP/linear, IgG, C3	Yes	URI, HC	S,C,P	Recovered
12, 1993	x, M	75	x	x/linear, IgG	Yes	x	S,P	Died
13, 1993	x, F	13	Yes	Cr/linear, IgG, C3	Yes	x	S	Recovered
13, 1993	x, F	17	Yes	Cr/linear, IgG, C3	Yes	URI, tobacco	S,C	Died
14, 1993	x, F	19	Yes	x	Yes	Tobacco, HC	x	HD
15, 1994	W, M	31	Yes	Cr/linear, IgG	Yes	Tobacco, possible HC	S,C,Az	Awaiting transplant
16, 1994	B, M	60	No	Cr/IgG, C3	No	None	S,C,P	Died
16, 1994	B, M	56	Yes	x	Yes	Tobacco	S,C,P	HD, awaiting transplant
16, 1994	B, M	29	Yes	x	Yes	URI	S,C,P	Died
16, 1994	W, M	45	Yes	Cr/IgG, IgA, IgM, C3	Yes	Tobacco, possible HC	S,C,P	HD
16, 1994	W, M	60	Yes	PM/linear	Yes	Possible HC	x	Normal renal function
16, 1994	W, M	21	Yes	x	Yes	Tobacco, possible HC	S,C,P	Died (PH)
16, 1994	B, F	26	Yes	Me/linear, IgG, C3	No	URI, tobacco	S,C,P	Recovered
16, 1994	W, F	59	Yes	Cr/linear, IgG, IgM	Yes	URI, tobacco, possible HC	S,C,P	Recovered
16, 1994	W, F	65	Yes	Cr/linear, IgG	Yes	None	S,C,P	Died
17, 1994	x, M	x	Yes	x	Yes	x	S,C,P	Transplantation
18, 1994	x, F	40	Yes	x	Yes	Tobacco	x	Transplantation
19, 1994	W, x	30	x	x	x	x	x	HD
20, 1994	x, M	21	No	RP/linear, IgG	Yes	x	Az, HD	x
21, 1994	x, F	72	x	Cr/x	Yes	x	HD	HD
22, 1995	x, F	67	No	Cr/linear, IgG	Yes	x	HD	HD
22, 1995	x, M	75	Yes	x	Yes	Tobacco	HD	HD
22, 1995	x, M	79	Yes	x	Yes	None	HD, S	Died
22, 1995	x, F	70	No	x	Yes	None	HD	HD
22, 1995	x, F	9	Yes	x	Yes	None	HD, S	HD
22, 1995	x, M	34	No	x	Yes	None	HD	HD
22, 1995	x, M	23	No	x	Yes	Tobacco	HD, S	HD
22, 1995	x, F	52	Yes	x	Yes	None	HD, S	HD
22, 1995	x, F	64	Yes	x	Yes	None	HD, S	HD
22, 1995	x, F	77	Yes	x	Yes	None	HD, S	Died
22, 1995	x, F	27	No	x	Yes	None	HD	HD
22, 1995	x, M	31	No	x	Yes	Tobacco	HD	HD
22, 1995	x, M	77	No	x	Yes	Tobacco	HD	HD
22, 1995	x, M	25	Yes	x	Yes	Tobacco	S	HD
22, 1995	x, F	15	No	x	Yes	None	HD, S	HD
23, 1995	W, M	24	Yes	x/IgG,C3	Yes	x	S,C,P	x
25, 1995	x, F	70	No	Cr/linear, IgG, C3	Yes	None	S, P, HD	x
26, 1995	x, F	72	x	Cr/linear, IgG	Yes	x	S,C	HD
27, 1995	x, M	24	Yes	C/x	Yes	x	S,C,P	x
28, 1995	B, M	57	Yes	Cr/IgG, C3	Yes	x	S,C,P	HD
29, 1996	W, M	72	Yes	Cr/x	Yes	Tobacco history	S,C,P	Died
30, 1996	x, M	65	No	x/linear	Yes	None	S	x
31, 1996	W, M	59	Yes	FS, Cr/linear IgG	Yes	Tobacco history, possible HC	S,C	x
32, 1996	x, M	11	Yes	x	x	x	x	HD
33, 1996	W, M	20	Yes	Cr/IgG	Yes	Tobacco	S,C,P	Transplantation
34, 1996	x, M	22	Yes	x	Yes	URI, tobacco, HC	S,C,P	Recovered
35, 1996	W, M	68	No	Cr/linear, IgG	Yes	x	S,C,P	Died (CVA)
36, 1996	W, F	49	Yes	x	Yes	Tobacco history	S,P,Az	HD
37, 1996	x, F	22	Yes	x	x	x	S, HD	Transplantation
38, 1997	W, F	21	Yes	Cr/linear, IgG	Yes	URI, possible tobacco	HD	x
39, 1997	W, F	53	No	Cr, FS/linear, IgG	Yes	x	S,C,P,Az,HD	Recovered
40, 1997	x, M	32	Yes	x/linear, IgG	Yes	Tobacco	x	HD
41, 1997	x, F	68	x	Cr/linear, IgG	Yes	Tobacco	x	Died (CVA)
42, 1997	x, M	70	Yes	Cr/linear, IgG	No	Tobacco	S,C,P,HD	Died
43, 1997	x, F	19	Yes	Normal/linear, IgG	Yes	Tobacco	S,C	Recovered
44, 1998	W, M	57	No	Cr/IgG	Yes	None	S,C,P	Recovered
45, 1998	W, M	49	Yes	x/IgG	Yes	URI	S,C,P	HD
46, 1998	x, F	44	Yes	Cr/linear	Yes	x	S,P,HD	Died (RF)
47, 1998	x, F	73	Yes	x/linear IgG	Yes	x	S	Died (RF)
48, 1998	x, M	18	Yes	Cr/linear	Yes	x	S,C,P	Transplantation
49, 1998	x, F	78	Yes	Cr/linear, IgG, C3	Yes	x	S,C,P	PD
49, 1998	x, M	65	x	Cr/IgG, C3	Yes	x	S,C,P	HD
50, 1998	W, M	18	Yes	Cr/linear, IgG, C3	Yes	URI, tobacco	S,P,HD	Recovered
51, 1998	x, F	71	Yes	Cr/linear, IgG, C3	Yes	x	S,C,P	Died
52, 1998	W, F	20	Yes	Cr/linear, IgG	Yes	x	S,C,P	Recovered
52, 1998	W, F	63	x	Cr/linear, IgG	Yes	x	S,C,P	Transplantation
53, 1999	x, M	54	Yes	x/IgA	Yes (IgA)	Possible HC	S,C,P	Recovered
54, 1999	W, M	21	Yes	Normal/linear, IgG, C3	No	URI, tobacco	S,C	Recovered
55, 1999	x, M	67	x	Cr/linear, IgA	Yes (IgA)	Tobacco	S,C	Died
56, 1999	x, M	35	Yes	Cr/linear, IgG, C3	Yes	Tobacco	S,C	HD, awaiting transplant
57, 1999	x, M	39	Yes	Cr/linear, IgG, C3	Yes	URI, possible HC	S, P, Az	Transplantation
58, 1999	W, M	23	Yes	FS/linear	Yes	Tobacco	S,P	x
59, 2000	x, M	19	Yes	Cr/linear, IgG	Yes	None	S,C,P,HD,MY	Transplantation
60, 2000	x, M	20	Yes	GS,Cr/linear, IgG	Yes	x	S,C,P,HD	HD
61, 2000	x, F	18	Yes	Cr/linear, IgG	No	HLA-DR2	S,C,HD,Im	Recovered
61, 2000	x, F	26	Yes	Cr/linear, IgG	Yes	HLA-DR2	S, Im	Recovered

Table 1. Case Reports of Goodpasture's Syndrome Between 1993 and 2000
Reference, Year	Race Sex	Age	Pulmonary Hemorrhage	Type GN	Anti-GBM (Serum)	Risk Factors	Treatment	Outcome
5, 1993	x, M	47	x	x/linear, IgG, IgA	Yes	Tobacco	C, P	x
6, 1993	x, M	59	x	Cr/linear, IgG	Yes	x	S,C,P,HD	HD
6, 1993	x, F	17	No	Cr/linear, IgG	Yes	x	S,C	x
7, 1993	W, M	25	x	x	x	x	S,P	Transplantation
8, 1993	W, F	23	No	Cr/linear, IgG	No	URI, tobacco	S,P,Az	Recovered
9, 1993	x, M	40	Yes	x	Yes	x	S,C,P	HD
9, 1993	x, M	58	Yes	Cr/x	Yes	x	S,C,P	HD
10, 1993	W, M	24	Probably	Normal/linear, IgG, C3	No	HC	S,C,P	Recovered
11, 1993	x, M	26	Yes	RP/linear, IgG, C3	Yes	URI, HC	S,C,P	Recovered
12, 1993	x, M	75	x	x/linear, IgG	Yes	x	S,P	Died
13, 1993	x, F	13	Yes	Cr/linear, IgG, C3	Yes	x	S	Recovered
13, 1993	x, F	17	Yes	Cr/linear, IgG, C3	Yes	URI, tobacco	S,C	Died
14, 1993	x, F	19	Yes	x	Yes	Tobacco, HC	x	HD
15, 1994	W, M	31	Yes	Cr/linear, IgG	Yes	Tobacco, possible HC	S,C,Az	Awaiting transplant
16, 1994	B, M	60	No	Cr/IgG, C3	No	None	S,C,P	Died
16, 1994	B, M	56	Yes	x	Yes	Tobacco	S,C,P	HD, awaiting transplant
16, 1994	B, M	29	Yes	x	Yes	URI	S,C,P	Died
16, 1994	W, M	45	Yes	Cr/IgG, IgA, IgM, C3	Yes	Tobacco, possible HC	S,C,P	HD
16, 1994	W, M	60	Yes	PM/linear	Yes	Possible HC	x	Normal renal function
16, 1994	W, M	21	Yes	x	Yes	Tobacco, possible HC	S,C,P	Died (PH)
16, 1994	B, F	26	Yes	Me/linear, IgG, C3	No	URI, tobacco	S,C,P	Recovered
16, 1994	W, F	59	Yes	Cr/linear, IgG, IgM	Yes	URI, tobacco, possible HC	S,C,P	Recovered
16, 1994	W, F	65	Yes	Cr/linear, IgG	Yes	None	S,C,P	Died
17, 1994	x, M	x	Yes	x	Yes	x	S,C,P	Transplantation
18, 1994	x, F	40	Yes	x	Yes	Tobacco	x	Transplantation
19, 1994	W, x	30	x	x	x	x	x	HD
20, 1994	x, M	21	No	RP/linear, IgG	Yes	x	Az, HD	x
21, 1994	x, F	72	x	Cr/x	Yes	x	HD	HD
22, 1995	x, F	67	No	Cr/linear, IgG	Yes	x	HD	HD
22, 1995	x, M	75	Yes	x	Yes	Tobacco	HD	HD
22, 1995	x, M	79	Yes	x	Yes	None	HD, S	Died
22, 1995	x, F	70	No	x	Yes	None	HD	HD
22, 1995	x, F	9	Yes	x	Yes	None	HD, S	HD
22, 1995	x, M	34	No	x	Yes	None	HD	HD
22, 1995	x, M	23	No	x	Yes	Tobacco	HD, S	HD
22, 1995	x, F	52	Yes	x	Yes	None	HD, S	HD
22, 1995	x, F	64	Yes	x	Yes	None	HD, S	HD
22, 1995	x, F	77	Yes	x	Yes	None	HD, S	Died
22, 1995	x, F	27	No	x	Yes	None	HD	HD
22, 1995	x, M	31	No	x	Yes	Tobacco	HD	HD
22, 1995	x, M	77	No	x	Yes	Tobacco	HD	HD
22, 1995	x, M	25	Yes	x	Yes	Tobacco	S	HD
22, 1995	x, F	15	No	x	Yes	None	HD, S	HD
23, 1995	W, M	24	Yes	x/IgG,C3	Yes	x	S,C,P	x
25, 1995	x, F	70	No	Cr/linear, IgG, C3	Yes	None	S, P, HD	x
26, 1995	x, F	72	x	Cr/linear, IgG	Yes	x	S,C	HD
27, 1995	x, M	24	Yes	C/x	Yes	x	S,C,P	x
28, 1995	B, M	57	Yes	Cr/IgG, C3	Yes	x	S,C,P	HD
29, 1996	W, M	72	Yes	Cr/x	Yes	Tobacco history	S,C,P	Died
30, 1996	x, M	65	No	x/linear	Yes	None	S	x
31, 1996	W, M	59	Yes	FS, Cr/linear IgG	Yes	Tobacco history, possible HC	S,C	x
32, 1996	x, M	11	Yes	x	x	x	x	HD
33, 1996	W, M	20	Yes	Cr/IgG	Yes	Tobacco	S,C,P	Transplantation
34, 1996	x, M	22	Yes	x	Yes	URI, tobacco, HC	S,C,P	Recovered
35, 1996	W, M	68	No	Cr/linear, IgG	Yes	x	S,C,P	Died (CVA)
36, 1996	W, F	49	Yes	x	Yes	Tobacco history	S,P,Az	HD
37, 1996	x, F	22	Yes	x	x	x	S, HD	Transplantation
38, 1997	W, F	21	Yes	Cr/linear, IgG	Yes	URI, possible tobacco	HD	x
39, 1997	W, F	53	No	Cr, FS/linear, IgG	Yes	x	S,C,P,Az,HD	Recovered
40, 1997	x, M	32	Yes	x/linear, IgG	Yes	Tobacco	x	HD
41, 1997	x, F	68	x	Cr/linear, IgG	Yes	Tobacco	x	Died (CVA)
42, 1997	x, M	70	Yes	Cr/linear, IgG	No	Tobacco	S,C,P,HD	Died
43, 1997	x, F	19	Yes	Normal/linear, IgG	Yes	Tobacco	S,C	Recovered
44, 1998	W, M	57	No	Cr/IgG	Yes	None	S,C,P	Recovered
45, 1998	W, M	49	Yes	x/IgG	Yes	URI	S,C,P	HD
46, 1998	x, F	44	Yes	Cr/linear	Yes	x	S,P,HD	Died (RF)
47, 1998	x, F	73	Yes	x/linear IgG	Yes	x	S	Died (RF)
48, 1998	x, M	18	Yes	Cr/linear	Yes	x	S,C,P	Transplantation
49, 1998	x, F	78	Yes	Cr/linear, IgG, C3	Yes	x	S,C,P	PD
49, 1998	x, M	65	x	Cr/IgG, C3	Yes	x	S,C,P	HD
50, 1998	W, M	18	Yes	Cr/linear, IgG, C3	Yes	URI, tobacco	S,P,HD	Recovered
51, 1998	x, F	71	Yes	Cr/linear, IgG, C3	Yes	x	S,C,P	Died
52, 1998	W, F	20	Yes	Cr/linear, IgG	Yes	x	S,C,P	Recovered
52, 1998	W, F	63	x	Cr/linear, IgG	Yes	x	S,C,P	Transplantation
53, 1999	x, M	54	Yes	x/IgA	Yes (IgA)	Possible HC	S,C,P	Recovered
54, 1999	W, M	21	Yes	Normal/linear, IgG, C3	No	URI, tobacco	S,C	Recovered
55, 1999	x, M	67	x	Cr/linear, IgA	Yes (IgA)	Tobacco	S,C	Died
56, 1999	x, M	35	Yes	Cr/linear, IgG, C3	Yes	Tobacco	S,C	HD, awaiting transplant
57, 1999	x, M	39	Yes	Cr/linear, IgG, C3	Yes	URI, possible HC	S, P, Az	Transplantation
58, 1999	W, M	23	Yes	FS/linear	Yes	Tobacco	S,P	x
59, 2000	x, M	19	Yes	Cr/linear, IgG	Yes	None	S,C,P,HD,MY	Transplantation
60, 2000	x, M	20	Yes	GS,Cr/linear, IgG	Yes	x	S,C,P,HD	HD
61, 2000	x, F	18	Yes	Cr/linear, IgG	No	HLA-DR2	S,C,HD,Im	Recovered
61, 2000	x, F	26	Yes	Cr/linear, IgG	Yes	HLA-DR2	S, Im	Recovered

Table 3. Common Laboratory Abnormalities in Patients With Goodpasture's Syndrome
Laboratory	No. of Patients
Hemoglobin
<12	33/37 (89%)
Normal	4/37 (11%)
Blood urea nitrogen
Increased	27/36 (75%)
Normal	9/36 (25%)
Creatinine
Increased	35/49 (71%)
Normal	14/49 (29%)
Urinalysis
Proteinuria	41/60 (68%)
Hematuria	43/60 (72%)
Granular casts	7/60 (12%)
Normal	4/60 (7%)

Table 3. Common Laboratory Abnormalities in Patients With Goodpasture's Syndrome
Laboratory	No. of Patients
Hemoglobin
<12	33/37 (89%)
Normal	4/37 (11%)
Blood urea nitrogen
Increased	27/36 (75%)
Normal	9/36 (25%)
Creatinine
Increased	35/49 (71%)
Normal	14/49 (29%)
Urinalysis
Proteinuria	41/60 (68%)
Hematuria	43/60 (72%)
Granular casts	7/60 (12%)
Normal	4/60 (7%)

Table 1. Case Reports of Goodpasture's Syndrome Between 1993 and 2000
Reference, Year	Race Sex	Age	Pulmonary Hemorrhage	Type GN	Anti-GBM (Serum)	Risk Factors	Treatment	Outcome
5, 1993	x, M	47	x	x/linear, IgG, IgA	Yes	Tobacco	C, P	x
6, 1993	x, M	59	x	Cr/linear, IgG	Yes	x	S,C,P,HD	HD
6, 1993	x, F	17	No	Cr/linear, IgG	Yes	x	S,C	x
7, 1993	W, M	25	x	x	x	x	S,P	Transplantation
8, 1993	W, F	23	No	Cr/linear, IgG	No	URI, tobacco	S,P,Az	Recovered
9, 1993	x, M	40	Yes	x	Yes	x	S,C,P	HD
9, 1993	x, M	58	Yes	Cr/x	Yes	x	S,C,P	HD
10, 1993	W, M	24	Probably	Normal/linear, IgG, C3	No	HC	S,C,P	Recovered
11, 1993	x, M	26	Yes	RP/linear, IgG, C3	Yes	URI, HC	S,C,P	Recovered
12, 1993	x, M	75	x	x/linear, IgG	Yes	x	S,P	Died
13, 1993	x, F	13	Yes	Cr/linear, IgG, C3	Yes	x	S	Recovered
13, 1993	x, F	17	Yes	Cr/linear, IgG, C3	Yes	URI, tobacco	S,C	Died
14, 1993	x, F	19	Yes	x	Yes	Tobacco, HC	x	HD
15, 1994	W, M	31	Yes	Cr/linear, IgG	Yes	Tobacco, possible HC	S,C,Az	Awaiting transplant
16, 1994	B, M	60	No	Cr/IgG, C3	No	None	S,C,P	Died
16, 1994	B, M	56	Yes	x	Yes	Tobacco	S,C,P	HD, awaiting transplant
16, 1994	B, M	29	Yes	x	Yes	URI	S,C,P	Died
16, 1994	W, M	45	Yes	Cr/IgG, IgA, IgM, C3	Yes	Tobacco, possible HC	S,C,P	HD
16, 1994	W, M	60	Yes	PM/linear	Yes	Possible HC	x	Normal renal function
16, 1994	W, M	21	Yes	x	Yes	Tobacco, possible HC	S,C,P	Died (PH)
16, 1994	B, F	26	Yes	Me/linear, IgG, C3	No	URI, tobacco	S,C,P	Recovered
16, 1994	W, F	59	Yes	Cr/linear, IgG, IgM	Yes	URI, tobacco, possible HC	S,C,P	Recovered
16, 1994	W, F	65	Yes	Cr/linear, IgG	Yes	None	S,C,P	Died
17, 1994	x, M	x	Yes	x	Yes	x	S,C,P	Transplantation
18, 1994	x, F	40	Yes	x	Yes	Tobacco	x	Transplantation
19, 1994	W, x	30	x	x	x	x	x	HD
20, 1994	x, M	21	No	RP/linear, IgG	Yes	x	Az, HD	x
21, 1994	x, F	72	x	Cr/x	Yes	x	HD	HD
22, 1995	x, F	67	No	Cr/linear, IgG	Yes	x	HD	HD
22, 1995	x, M	75	Yes	x	Yes	Tobacco	HD	HD
22, 1995	x, M	79	Yes	x	Yes	None	HD, S	Died
22, 1995	x, F	70	No	x	Yes	None	HD	HD
22, 1995	x, F	9	Yes	x	Yes	None	HD, S	HD
22, 1995	x, M	34	No	x	Yes	None	HD	HD
22, 1995	x, M	23	No	x	Yes	Tobacco	HD, S	HD
22, 1995	x, F	52	Yes	x	Yes	None	HD, S	HD
22, 1995	x, F	64	Yes	x	Yes	None	HD, S	HD
22, 1995	x, F	77	Yes	x	Yes	None	HD, S	Died
22, 1995	x, F	27	No	x	Yes	None	HD	HD
22, 1995	x, M	31	No	x	Yes	Tobacco	HD	HD
22, 1995	x, M	77	No	x	Yes	Tobacco	HD	HD
22, 1995	x, M	25	Yes	x	Yes	Tobacco	S	HD
22, 1995	x, F	15	No	x	Yes	None	HD, S	HD
23, 1995	W, M	24	Yes	x/IgG,C3	Yes	x	S,C,P	x
25, 1995	x, F	70	No	Cr/linear, IgG, C3	Yes	None	S, P, HD	x
26, 1995	x, F	72	x	Cr/linear, IgG	Yes	x	S,C	HD
27, 1995	x, M	24	Yes	C/x	Yes	x	S,C,P	x
28, 1995	B, M	57	Yes	Cr/IgG, C3	Yes	x	S,C,P	HD
29, 1996	W, M	72	Yes	Cr/x	Yes	Tobacco history	S,C,P	Died
30, 1996	x, M	65	No	x/linear	Yes	None	S	x
31, 1996	W, M	59	Yes	FS, Cr/linear IgG	Yes	Tobacco history, possible HC	S,C	x
32, 1996	x, M	11	Yes	x	x	x	x	HD
33, 1996	W, M	20	Yes	Cr/IgG	Yes	Tobacco	S,C,P	Transplantation
34, 1996	x, M	22	Yes	x	Yes	URI, tobacco, HC	S,C,P	Recovered
35, 1996	W, M	68	No	Cr/linear, IgG	Yes	x	S,C,P	Died (CVA)
36, 1996	W, F	49	Yes	x	Yes	Tobacco history	S,P,Az	HD
37, 1996	x, F	22	Yes	x	x	x	S, HD	Transplantation
38, 1997	W, F	21	Yes	Cr/linear, IgG	Yes	URI, possible tobacco	HD	x
39, 1997	W, F	53	No	Cr, FS/linear, IgG	Yes	x	S,C,P,Az,HD	Recovered
40, 1997	x, M	32	Yes	x/linear, IgG	Yes	Tobacco	x	HD
41, 1997	x, F	68	x	Cr/linear, IgG	Yes	Tobacco	x	Died (CVA)
42, 1997	x, M	70	Yes	Cr/linear, IgG	No	Tobacco	S,C,P,HD	Died
43, 1997	x, F	19	Yes	Normal/linear, IgG	Yes	Tobacco	S,C	Recovered
44, 1998	W, M	57	No	Cr/IgG	Yes	None	S,C,P	Recovered
45, 1998	W, M	49	Yes	x/IgG	Yes	URI	S,C,P	HD
46, 1998	x, F	44	Yes	Cr/linear	Yes	x	S,P,HD	Died (RF)
47, 1998	x, F	73	Yes	x/linear IgG	Yes	x	S	Died (RF)
48, 1998	x, M	18	Yes	Cr/linear	Yes	x	S,C,P	Transplantation
49, 1998	x, F	78	Yes	Cr/linear, IgG, C3	Yes	x	S,C,P	PD
49, 1998	x, M	65	x	Cr/IgG, C3	Yes	x	S,C,P	HD
50, 1998	W, M	18	Yes	Cr/linear, IgG, C3	Yes	URI, tobacco	S,P,HD	Recovered
51, 1998	x, F	71	Yes	Cr/linear, IgG, C3	Yes	x	S,C,P	Died
52, 1998	W, F	20	Yes	Cr/linear, IgG	Yes	x	S,C,P	Recovered
52, 1998	W, F	63	x	Cr/linear, IgG	Yes	x	S,C,P	Transplantation
53, 1999	x, M	54	Yes	x/IgA	Yes (IgA)	Possible HC	S,C,P	Recovered
54, 1999	W, M	21	Yes	Normal/linear, IgG, C3	No	URI, tobacco	S,C	Recovered
55, 1999	x, M	67	x	Cr/linear, IgA	Yes (IgA)	Tobacco	S,C	Died
56, 1999	x, M	35	Yes	Cr/linear, IgG, C3	Yes	Tobacco	S,C	HD, awaiting transplant
57, 1999	x, M	39	Yes	Cr/linear, IgG, C3	Yes	URI, possible HC	S, P, Az	Transplantation
58, 1999	W, M	23	Yes	FS/linear	Yes	Tobacco	S,P	x
59, 2000	x, M	19	Yes	Cr/linear, IgG	Yes	None	S,C,P,HD,MY	Transplantation
60, 2000	x, M	20	Yes	GS,Cr/linear, IgG	Yes	x	S,C,P,HD	HD
61, 2000	x, F	18	Yes	Cr/linear, IgG	No	HLA-DR2	S,C,HD,Im	Recovered
61, 2000	x, F	26	Yes	Cr/linear, IgG	Yes	HLA-DR2	S, Im	Recovered

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Characteristics and Outcomes of Patients With Goodpasture's Syndrome

Materials and Methods

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