Membranous Glomerulonephritis in a Patient With Choriocarcinoma: Case Report

Mehmet Riza Altiparmak, MD, Ömer Nuri Pamuk, MD, Gülsüm Emel Pamuk, MD, Gülsen Özbay, MD


South Med J. 2003;96(2) 

In This Article

Abstract and Introduction

A 26-year-old woman presented at our hospital with pretibial edema, swelling, and vaginal bleeding. She had nephrotic-level proteinuria and was diagnosed with choriocarcinoma after a histologic examination of her uterine curetting was performed. The renal biopsy specimen was compatible with membranous glomerulonephritis. The renal pathology in this case was thought to be secondary to choriocarcinoma because the nephrotic syndrome regressed after hysterectomy. We briefly present this first case of choriocarcinoma causing membranous glomerulonephritis.

Choriocarcinoma is a malignant tumor derived from trophoblasts that has high metastatic potential.[1] Rapid dissemination by the hematogenous or lymphatic route to the lungs, brain, and, rarely, kidneys is possible.[2] Renal involvement by choriocarcinoma has been reported to have an incidence of 1.3%.[3] Membranous glomerulonephritis (MGN) might be secondary to drug use, systemic lupus erythematosus, tumors, or hepatitis B virus infection.[4] An underlying malignancy may coexist with MGN in 6 to 11% of patients.[5,6] We report the first case described in the literature of a patient who developed MGN at the time of presentation with choriocarcinoma and whose nephrotic syndrome regressed after resection of the tumor.


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