The use of permanent hair dyes in women was associated with a borderline increase in the risk of developing SLE, with higher risk among those with a longer duration of dye use in the CLU study.[18*] Although one previous study reported a strong association between the use of hair dyes and connective tissue disease, other studies that have evaluated the association of this exposure specifically with the onset of SLE have found no association.[33,34,35] As with smoking, there are large variations in the chemical content of hair dyes (International Agency for Research on Cancer 1993). The weak association appreciated in the CLU study[18*] makes it difficult to discount the potential contribution of some ingredients within permanent dyes as possible promoters or contributing causal components in conjunction with other exposures to the development of SLE. However, the difficulty posed by recall of specific products used, and changes in products over time makes this a particularly complex exposure to study.
Curr Opin Rheumatol. 2003;15(2) © 2003 Lippincott Williams & Wilkins
Cite this: Environmental Epidemiology and Risk Factors for Autoimmune Disease - Medscape - Mar 01, 2003.