Nonmyeloablative Allogeneic Stem-Cell Transplantation for Hematologic Malignancies: A Systematic Review

Benjamin Djulbegovic, MD, PhD, Jerome Seidenfeld, PhD, Claudia Bonnell, BSN, MLS, Ambuj Kumar, MD, MPH

Cancer Control. 2003;10(1) 

In This Article


We searched the MEDLINE computer database for reports from 1995 through June 2002 using the following search terms: (nonmyeloablat* OR "transplant lite" OR "mini-transplant" OR "mini-allograft*" OR graft-vs-host disease (mh)) AND explode hematologic neoplasms (mh) AND human. Similar terms were used to search the EMBASE database. Computer searches were supplemented by manual reviews of bibliographies of selected references, reviews of meeting abstracts from key hematology/oncology meetings, and reviews of Current Contents, an electronic resource that provides access to bibliographic research information.

A flow diagram of our search results and selection process is shown in Figure 2. We initially identified 308 studies for potential retrieval. After further review, we excluded 283 studies, including review articles containing no primary data, abstracts that were later available as full reports, duplicate studies, reports on nonhematologic malignancies, studies on T-cell depletion and donor-lymphocyte infusion, reports on discussions at conferences about NM-allo-SCT, and reports involving fewer than 5 patients. Data were extracted from the remaining 25 studies, which included 23 published as full reports, one abstract, and one letter.

Flow diagram showing identification of the papers for inclusion in the systematic review.


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