The Use of Bisphosphonates in Patients With Breast Cancer

Catherine H. Van Poznak, MD

Disclosures

Cancer Control. 2002;9(6) 

In This Article

Long-Term Use of Intravenous Bisphosphonates

To assess for safety and efficacy of long-term intravenous bisphosphonate therapy, Ali et al[25] studied cancer patients receiving pamidronate or zoledronic acid for longer than 2 years. Of the 22 patients identified, 5 were men with multiple myeloma and 17 were women with metastatic breast cancer. The median duration of follow-up was 3.6 years (range 2.2 to 6.0 years). During the first 2 years of treatment with either pamidronate or zoledronic acid, 6 of the 22 patients developed a pathologic fracture or received radiation therapy. Skeletal events that occurred after the first 2 years of bisphosphonate therapy included fractures in 4 of the 22 patients. There was no clinically relevant change in complete blood cell counts, platelet counts, calcium and electrolyte analysis, or kidney function for these patients receiving long-term intravenous bisphosphonate therapy. Long-term use of pamidronate and zoledronic acid appears to be well tolerated.

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