Obsessive-Compulsive Disorder: Towards Better Understanding and Outcomes

Kenneth C. Kirkby


Curr Opin Psychiatry. 2003;16(1) 

In This Article

Brain Imaging

Biological processes in the brain, particularly involving the corticostriatalthalamic system, whilst of major interest, receive limited attention because of the technical requirements and cost of imaging research. Hansen et al.[42**] used positron emission tomography to study glucose metabolism changes associated with three months of paroxetine treatment in 20 non-depressed OCD patients. Metabolism reduced post-treatment in the right caudate nucleus, and positively correlated with symptom severity. Saxena et al.[43*,44**] extended this finding in a comparison of depressed, OCD and comorbid patients treated with selective serotonin reuptake inhibitors (SSRI). They reported both disorder and response specificity in brain changes, that is depression and OCD differed from each other, as did changes following treatment response. Sachdev[45*] reported analogous but more extensive metabolic alterations in a single case study following cingulotomy.


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