Cognitive Dysfunction in Neuropsychiatric Systemic Lupus Erythematosus

Melanie J. Harrison, MD, MS, Lisa D. Ravdin, PhD


Curr Opin Rheumatol. 2002;14(5) 

In This Article

Summary and Conclusion

The first decade and a half of the study of SLE-associated cognitive dysfunction focused primarily on its recognition and identification of patterns and risk factors. Despite the variability in study results, it is now generally well accepted that cognitive dysfunction is a clinically important manifestation of SLE with many etiologic factors contributing to its presentation. More recently, we have seen novel approaches to the study of SLE-associated cognitive dysfunction with respect to its etiology, imaging, and course. It is only through continued and unique research approaches that elucidating the nuances of this complex issue will be possible, with the additional goal of establishing effective treatment strategies for SLE patients with neuropsychiatric manifestations of disease.


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