Cognitive Dysfunction in Neuropsychiatric Systemic Lupus Erythematosus

Melanie J. Harrison, MD, MS, Lisa D. Ravdin, PhD


Curr Opin Rheumatol. 2002;14(5) 

In This Article

Patterns of Dysfunction as a Clue to Etiology and Pathogenesis

Many investigators continue to identify "patterns" of cognitive dysfunction to better understand its pathophysiology and etiology. Leritz et al.,[23] used a validated, empirically-derived equation that uses 11 items on the Mini Mental Status Examination to discriminate between cortical and subcortical damage in 93 SLE subjects without any neuropsychiatric history. They reported that 94.6% of the subjects reached scores consistent with subcortical deficits compared with 5.4% whose results suggested cortical deficits. The authors concluded that most cognitive dysfunction identified in SLE patients without frank neuropsychiatric disease was more similar to Huntington's disease, a subcortical dementia, rather than Alzheimer's disease.


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