Systemic Lupus Erythematosus and Antiphospholipid Antibody Syndrome

Peggy Lin, MD, Tania J. Phillips, MD, FRCPC


Wounds. 2002;14(6) 

In This Article


A 40-year-old Caucasian woman with systemic lupus erythematosus presented with a 10-day history of blisters on her right shin. The blisters were filled with a clear fluid and were painful. She noted surrounding erythema and warmth around the blisters but denied fevers or chills. She did not have any blisters in her mouth or on her genitalia. She treated the area with hydrocortisone valerate cream and had been started on minocycline by her primary care physician. Her other medications included methotrexate, chloroquine, warfarin, celecoxib, folic acid, and acetaminophen. She was adopted and unaware of any family history of blistering disease. Her main manifestations of systemic lupus erythematosus were fatigue and mouth sores, as well as joint pains in her knees and hands. She has had a history of renal disease, alopecia, and butterfly rash. She has also had two prior episodes of deep venous thromboses and a history of a leg ulcer, which healed but was complicated by cellulitis.


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