Epidemiologic Response to Anthrax Outbreaks: Field Investigations, 1950-2001

Michael E. Bales, Andrew L. Dannenberg, Philip S. Brachman, Arnold F. Kaufmann,Peter C. Klatsky, David A. Ashford

Disclosures

Emerging Infectious Diseases. 2002;8(10) 

In This Article

Abstract and Introduction

We used unpublished reports, published manuscripts, and communication with investigators to identify and summarize 49 anthrax-related epidemiologic field investigations conducted by the Centers for Disease Control and Prevention from 1950 to August 2001. Of 41 investigations in which Bacillus anthracis caused human or animal disease, 24 were in agricultural settings, 11 in textile mills, and 6 in other settings. Among the other investigations, two focused on building decontamination, one was a response to bioterrorism threats, and five involved other causes. Knowledge gained in these investigations helped guide the public health response to the October 2001 intentional release of B. anthracis, especially by addressing the management of anthrax threats, prevention of occupational anthrax, use of antibiotic prophylaxis in exposed persons, use of vaccination, spread of B. anthracis spores in aerosols, clinical diagnostic and laboratory confirmation methods, techniques for environmental sampling of exposed surfaces, and methods for decontaminating buildings.

The intentional release of Bacillus anthracis in October 2001 greatly challenged the U.S. public health system. Collaborating with partners in other federal, state, and local health agencies, the Centers for Disease Control and Prevention (CDC) responded to these bioterrorism events by relying on experience investigating public health aspects of anthrax over the past 50 years.[1] Topics addressed in these investigations included epidemiology, vaccines,[2,3] controlling anthrax in industrial and agricultural settings,[4] public health response to bioterrorism events,[5] B. anthracis contamination of milk and meat,[6] identifying B. anthracis-contaminated commercial products,[7] decontamination methods for contaminated environmental sites, and laboratory methods, among others.

Field studies conducted by the Epidemic Intelligence Service (EIS) constituted the cornerstone of these investigative efforts.[8] When invited by a state health department or national ministry of health, CDC's EIS Officers conduct field investigations, Epidemic-Aids (known as Epi-Aids), in response to acute public health needs in the United States and other countries. Recently, historic documents from >4,000 Epi-Aids (approximately 90% domestic, 10% international) from 1950 to 1999 were made more accessible through the creation of an internal, searchable electronic database. It includes many unpublished CDC reports on early anthrax investigations, which form the basis of this report.

B. anthracis, the gram-positive, spore-forming, rod-shaped bacterium that causes anthrax,[9] is most commonly a zoonotic pathogen. Human B. anthracis infections are rare in the United States; the number of cases has decreased steadily from an average of 35 reported cases per year in the 1950s to <1 reported case per year since 1980[10,11] ( Table 1 ). Most reported cases have been cutaneous. Before October 2001, the last case of inhalational anthrax in the United States occurred in 1976 (12,13).

To answer questions raised when the bioterrorism-related cases of anthrax were identified in October 2001, we reviewed results of field investigations of anthrax. We also identified current questions for which past experience with anthrax provided relatively little information and for which further research is needed.

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