Surgical Management of Bladder Carcinoma

Rafael Carrion, MD, John Seigne, MB

Disclosures

Cancer Control. 2002;9(4) 

In This Article

Appearance Suggesting a Superficial Tumor (Ta)

When the suspected diagnosis is superficial bladder cancer (based on the appearance of the tumor), consideration should be given to administering an immediate postoperative single intravesical dose of 40 mg of mitomycin C. In a randomized, controlled trial performed in Europe, a single postoperative intravesical administration of mitomycin C decreased the recurrence rate at 3 months from 55% to 40%.[6] Mitomycin C is presumed to act on the tumor cells that are released at the time of TUR by preventing their implantation and growth in deepithelialized areas created by the surgery.

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