Naloxone for the Reversal of Opioid Adverse Effects

Marcia L. Buck, PharmD, FCCP


Pediatr Pharm. 2002;8(8) 

In This Article


Naloxone remains an important antidote for the reversal of opioid-induced respiratory and CNS depression. It is also useful in the management of constipation and pruritus, where careful dose titration can produce relief without reversing analgesic efficacy. As our understanding of the role of naloxone in modulating endogenous opioids and opioid dependency grows, it is likely that its use will expand to an even wider variety of clinical settings in the future.


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