Naloxone for the Reversal of Opioid Adverse Effects

Marcia L. Buck, PharmD, FCCP


Pediatr Pharm. 2002;8(8) 

In This Article

Product Availability and Preparation

Naloxone is available as Narcan® (Endo Pharmaceuticals) and as a generic product. The 0.4 mg/ml strength is produced in 1 ml amps and 1 ml syringes, as well as 1, 2, and 10 ml vials. The 1 mg/ml concentration is available in 2 ml amps and 10 ml vials. The 0.02 mg/ml strength, referred to as the neonatal injection, is available in 2 ml amps or vials.[3] The use of this lower concentration is no longer recommended, as it can result in delivery of excessive fluid volumes. Naloxone may be diluted with normal saline or 5% dextrose solutions. It should not be mixed with preparations containing bisulfites or drugs with an alkaline pH.[28]


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.