Naloxone for the Reversal of Opioid Adverse Effects

Marcia L. Buck, PharmD, FCCP

Disclosures

Pediatr Pharm. 2002;8(8) 

In This Article

Product Availability and Preparation

Naloxone is available as Narcan® (Endo Pharmaceuticals) and as a generic product. The 0.4 mg/ml strength is produced in 1 ml amps and 1 ml syringes, as well as 1, 2, and 10 ml vials. The 1 mg/ml concentration is available in 2 ml amps and 10 ml vials. The 0.02 mg/ml strength, referred to as the neonatal injection, is available in 2 ml amps or vials.[3] The use of this lower concentration is no longer recommended, as it can result in delivery of excessive fluid volumes. Naloxone may be diluted with normal saline or 5% dextrose solutions. It should not be mixed with preparations containing bisulfites or drugs with an alkaline pH.[28]

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