Human Metapneumovirus as a Cause of Community-Acquired Respiratory Illness

Joanne Stockton, Iain Stephenson, Douglas Fleming, and Maria Zambon


Emerging Infectious Diseases. 2002;8(9) 

In This Article

Abstract and Introduction

Human metapneumovirus (HMPV) is a recently identified Paramyxovirus first isolated from hospitalized children with acute respiratory tract infections (ARTI). We sought evidence of HMPV infection in patients who had visited general practitioners, had influenzalike illnesses (ILI), and had negative tests for influenza and Human respiratory syncytial virus (HRSV). As part of national virologic surveillance, sentinel general practices in England and Wales collected samples from patients of all ages with ILI during winter 2000-01. Reverse transcriptase-polymerase chain reaction (PCR) for HMPV, influenza A (H1 and H3), influenza B, and HRSV (A and B) was used to screen combined nose and throat swabs. PCR products from the HMPV-positive samples were sequenced to confirm identity and construct phylogenetic trees. Of 711 swabs submitted, 408 (57.3%) were negative for influenza and HRSV; HMPV was identified in 9 (2.2%) patients. HMPV appears to be associated with community-acquired ARTI. The extent of illness and possible complications related to this new human virus need to be clarified.

Despite control of many infectious diseases in the industrialized world, acute viral respiratory tract infections (ARTI) remain a leading cause of illness. Although usually self-limiting in healthy adults, these infections are responsible for a substantial loss of productive time and are important factors in the illness and death of the elderly population. Various genetically diverse viruses, often with multiple types, may cause respiratory illness; of these, influenza receives the greatest attention.[1] Human respiratory syncytial virus (HRSV) is also increasingly implicated as an important pathogen.[2]

The association between the incidence of ARTI and excess winter deaths in the United Kingdom is well recognized.[1] Regression modeling associates excess winter deaths with influenza and HRSV but also suggests that other pathogens may be involved.[3]

Studies of the impact of respiratory virus infections are limited by difficulty in distinguishing respiratory pathogens clinically and in the laboratory.[4,5] Despite improved sensitivity with diagnostic techniques such as reverse transcriptase-polymerase chain reaction (RT-PCR), approximately 40% of specimens from patients with community-acquired respiratory illnesses during peak winter months contain no identified viral pathogen.[2,5,6]

A new pneumovirus, Human Metapneumovirus (HMPV), has recently been isolated in the Netherlands.[7] The Pneumovirinae subfamily is classified into Pneumovirus, containing HRSV, and Metapneumovirus genera. In 2001, Van den Hoogen et al.[7] reported the detection of HMPV in nasopharyngeal aspirates taken in a 10-year period from 28 hospitalized children and infants with respiratory tract infections who had signs and symptoms similar to those of HRSV infection.

Establishing sensitive methods for virus detection helps to clarify the relative contribution of different pathogens to the extent of illness in the community. This information is important for future development of specific antiviral therapies and vaccines. We examined specimens submitted from patients seen in general practice with influenzalike illnesses (ILI) during winter 2000-01 to detect HMPV as a possible cause of influenza- and HRSV-negative ILI.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.
Post as: