Infections in Oncology: Fulminant Hepatic Failure Due to Disseminated Adenovirus Infection in a Patient With Chronic Lymphocytic Leukemia

Eric B. Haura, MD, Mark A.Winden, PA, Alan D. Proia, MD, PhD, and James F. Trotter, MD


Cancer Control. 2002;9(3) 

In This Article


Adenovirus infection is a common cause of upper respiratory infection in which symptoms are usually mild and transient. Rarely, adenovirus may disseminate, resulting in pneumonitis, severe hepatic necrosis, and fulminant hepatic failure.[1] Such cases have been reported in two types of patients: those with a primary immunodeficiency (eg, thymic dysplasia, severe combined immunodeficiency or AIDS) and those with a secondary immunodeficiency (eg, immunosuppressive therapy or chemotherapy).[2] We report a case of fulminant hepatic failure caused by disseminated adenovirus infection in a patient with Rai stage 0 chronic lymphocytic leukemia (CLL) who had not received corticosteroid or cytotoxic chemotherapy.


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