Immunologic Aspects of Organ Transplantation

Susan Smith MN, PhD


June 17, 2002


The exact origin of the APC is unknown. APCs are formed in the epidermis, where they are called Langerhans cells. APCs play an important role in linking the innate immune system with the acquired immune system. APCs carry foreign antigens that enter the host via the respiratory tract, GI tract, or skin through the lymphatic system and present them to lymphocytes in the lymph nodes and spleen, thereby triggering cellular and humoral immune responses.