Feline Host Range of Canine parvovirus: Recent Emergence of New Antigenic Types in Cats

Yasuhiro Ikeda, Kazuya Nakamura, Takayuki Miyazawa, Yukinobu Tohya, Eiji Takahashi,Masami Mochizuki


Emerging Infectious Diseases. 2002;8(4) 

In This Article

Clinical Features of FPLV and CPV in Their Original Hosts

Parvoviruses replicate most efficiently in rapidly dividing cells. Replication is generally lytic, and tissue damage at these sites can be observed [17]. Infection with FPLV causes two typical syndromes. When infection occurs in fetuses or very young kittens, a distinct cerebellar ataxia is observed when they become actively ambulatory [18,19]. When older kittens are infected, illness characterized by loss of appetite, pyrexia, diarrhea, and leukopenia of both lymphocytes and neutrophils appears [20]. On the other hand, two typical syndromes observed in CPV-infected dogs are acute myocarditis in young puppies with a high mortality [21] and hemorrhagic enteritis in older puppies [4,22].

Mortality from FPLV infection is likely to depend on the general condition of the animals before infection. Experimental infection of specific pathogen-free (SPF) or germfree cats with FPLV generally leads to mild diseases [23,24]. No or slight intestinal lesions can be observed in infected germfree cats [23], which suggests that the intestinal lesions are caused by secondary bacterial, rather than primary viral, infection.


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