Feline Host Range of Canine parvovirus: Recent Emergence of New Antigenic Types in Cats

Yasuhiro Ikeda, Kazuya Nakamura, Takayuki Miyazawa, Yukinobu Tohya, Eiji Takahashi,Masami Mochizuki


Emerging Infectious Diseases. 2002;8(4) 

In This Article

Emergence of CPV Types 2a and 2b (CPV-2a and CPV-2b)

Since the emergence of CPV-2, two new antigenic types of CPV, designated CPV-2a and CPV-2b, have arisen consecutively. These new virus types have now almost completely replaced CPV-2 viruses as the dominant infectious agents [15] (Figure 3). At least four conserved nonsynonymous substitutions have been observed between CPV-2 and CPV-2a isolates in the VP2 gene ( Table 1 ). CPV-2b isolates have another two nonsynonymous changes from CPV-2a ( Table 1 ). Although the exact mechanisms of these evolutions are not clear, the emergence of these new antigenic types of CPV can likely be ascribed to the adaptation of CPV-2-type viruses in dogs. Of interest, each new antigenic type has lost at least one neutralizing epitope compared with the former serotype [16].


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.