Predicting the Risk of Lyme Disease: Habitat Suitability for Ixodes scapularis in the North Central United States

Marta Guerra, Edward Walker, Carl Jones, Susan Paskewitz, M. Roberto Cortinas, Ashley Stancil, Louisa Beck, Matthew Bobo, Uriel Kitron

Disclosures

Emerging Infectious Diseases. 2002;8(3) 

In This Article

Discussion

Ixodes scapularis may be introduced into new areas by several routes. Adult I. scapularis are carried into new areas primarily by deer[43], which are capable of ranging over wide areas, especially along riparian corridors. However, infected adult ticks have limited potential for spreading Lyme disease since transovarial transmission of B. burgdorferi is rare. Small mammals are efficient disease reservoirs, and juveniles tend to disperse during the spring and summer when tick larvae and nymphs are questing. However, the potential for long-range dispersal of Lyme disease by rodents is limited, since they occupy much smaller home ranges than deer[44]. Birds have a high potential for introducing infected immature stages of I. scapularis into distant areas[45,46,47], especially during spring and fall migration.

To become successfully established in a new area, I. scapularis requires available hosts for feeding, which is not a limiting factor in our study area, and a suitable habitat for questing, molting, diapause, and oviposition. The vegetation, soil, topography, and climate are interrelated, and extremes of any one factor may adversely affect the tick's ability to survive.

The environmental characteristics vary throughout the two states, and certain combinations may determine whether introduced I. scapularis populations can become established. Tick abundance is an indicator of the suitability of environmental conditions for reproduction and survival. Finding only one stage of the tick may indicate either a poor microenvironment or a recent introduction. Finding all three stages at one site strongly suggests that a population has become established. A less than optimal habitat may account for low density in an established I. scapularis population, or it may indicate a recent introduction. Errors in classification may occur in an extensive field survey, as reported here, and a dynamic situation (i.e., the process of invasion of a new site) may mask the occurrence of some positive or potentially positive sites. By including a large number of sites and conducting repeat visits, we have tried to minimize such confounding effects.

Environmental factors such as bedrock geology, quaternary deposits, soils, vegetation, and climate influence each other directly and indirectly to create unique habitats. This is why we included risk factors that are not necessarily independent in a model that is most unbiased. The soil orders in the region (Figure 4) are influenced by the type of underlying bedrock and by quaternary deposits. The soils, in turn, influence the type of vegetation overlying them. Soil texture is the component of soil that influences the extent of drainage. The soil texture classes are independent of soil order and are usually a function of the degree of soil weathering and the parent material (bedrock or quaternary deposit). The tree composition of a forest is determined by a moisture gradient involving soil aeration, soil nutrient supply, and microclimatic features[38], and this gradient functions as a continuum. The forest types classified as dry and dry/mesic have oaks and jack pines as the dominant species that prefer well-drained, sandy soils. Oak forests also have a dense canopy layer that provides protection for the underlying vegetation. Wet and wet/mesic forests are composed of trees that have a high tolerance for very moist soils. The factors interacting at the microclimatic level within the topsoil and leaf litter appear to have an important influence on tick survival. Excessively moist conditions at the soil level were negatively associated with the establishment of I. scapularis. Soil texture, in addition to the topography, determines the extent of drainage, and the level of moisture of the ground layer, regardless of the amount of precipitation. However, given the effect of weather on tick abundance[19], associations between tick presence and amount of yearly precipitation or snowfall need to be analyzed further.

Our findings suggest that abiotic factors play a major role in determining whether populations of I. scapularis can become established in an environment. Precambrian bedrock of volcanic origin results in the formation of acidic soils that are found mainly under coniferous forests, the forest type least likely to support tick populations. Soils containing increased acidity (spodosols) and a high proportion of clay that can retain excess moisture[48] were also more frequently present in negative sites. Excessive moisture in the soil may be deleterious to tick survival since they overwinter in the topsoil and leaf litter. It may also enhance the growth of organisms, such as fungi and entomophagous nematodes, which may have adverse effects on the tick population[49]. Leaf litter is a necessary component for the survival of immature stages of I. scapularis[50]. However, the type and quantity may determine the densities of ticks in a specific habitat. Tick densities were highest in forests dominated by oak, followed by maple, and lowest in coniferous forests that produce minimal amounts of leaf litter[38]. Tick densities were also highest in areas with underlying sedimentary bedrock, which is associated with alfisol and mollisol soil orders and soil textures of increased particle size[38].

The statistically significant risk factors derived from the logistic regression analysis were in agreement with those obtained from the discriminant analysis, and allowed us to quantify and predict the environmental risk for the presence of I. scapularis. Several environmental factors must be evaluated simultaneously to assess the combination of factors required for successful establishment. Determining the environmental factors that limit survival can facilitate the development of measures for the control of the tick in the environment.

Using a GIS, we generated a risk map (Figure 5) to predict the presence of the tick vector, I. scapularis. The areas of suitable habitat for I. scapularis in Wisconsin corresponded to areas of increased incidence of human Lyme disease and known areas of tick endemicity. The extensive area of suitable habitat in the western portion of the state can explain the rapid expansion of the tick from the original northwestern focus to the southwestern portion of the state[2,3,4,5]. While initial studies of tick distribution[3] and human granulocytic ehrlichiosis[51] point to the risk of tick-borne disease transmission in Northwest Wisconsin, our study points also to the sandy barrens of Central Wisconsin as most suitable habitats. Indeed, the highest numbers of ticks were collected in Council Ground State Park (Lincoln County), Fort McCoy (Monroe County), Hartman Creek State Park (Waupaca County), and Wildcat Mountain State Park (Vernon County), as well as in sites in the long-recognized Spooner area (Washburn County). Further, the highest prevalence of canine seropositivity to B. burgdorferi in northern Illinois and Wisconsin was found in dogs in the west-central counties of Wisconsin[52]. Based on the risk map, most of the north-central and northeastern portions of Wisconsin have a <25% probability for tick presence. These are areas where our sampled sites were consistently negative for I. scapularis. In the eastern half of the state, the main areas of increased suitability were along the glacial terminal moraines, which is where the positive sites in the Kettle Moraine State Forest were located. There was also a higher probability in the northeastern corner of the state bordering Menominee County, Michigan, where positive sites were located.

In Illinois, areas of increased suitability corresponded to the same areas where the positive sites were located in Ogle, Rock Island, and Jo Daviess counties. The risk map indicated there is adequate habitat for I. scapularis populations to become established along the Illinois River, as well as the Mississippi River. However, in Illinois, tick populations may be limited to river corridors since extensive areas are used for agriculture. Where forested habitat is sparse, tick establishment may be restricted, even though geologic and soil factors are favorable. In southern Illinois, where climatic conditions may differ and other reservoir hosts may be present, the inclusion of additional parameters to the model may result in reduced risk probabilities. In contrast, the risk factor model and predictive map may be valid for other north-central areas that have similar environmental characteristics, particularly in parts of Minnesota, Michigan, northern Indiana, and Ohio. The model may be applied to other areas of the United States by using local geographic coverages.

In conclusion, this model can be used to help determine the risk of acquiring Lyme disease and other diseases transmitted by I. scapularis by predicting which locations may be currently infested with the tick. It can also be used to assess whether habitats that are currently nonendemic for I. scapularis would have the necessary combination of environmental factors to allow new populations of I. scapularis to become established. The model can thus be continuously refined based on findings from new areas. The risk of Lyme disease transmission could be predicted in areas capable of sustaining I. scapularis populations if ticks harboring B. burgdorferi are introduced by migrating deer or birds. The results obtained from these field studies can also form the basis for controlled experimental studies under field and laboratory conditions to further elucidate the preferred microenvironment of I. scapularis.

Comments

3090D553-9492-4563-8681-AD288FA52ACE
Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.

processing....