Nutrition and Depression: The Role of Folate

Jonathan E. Alpert, MD, PhD, Maurizio Fava, MD


Medscape Psychiatry & Mental Health eJournal. 1997;2(1) 

In This Article


Although theoretical models of folate-depression interrelationships are clearly in need of a more empiric foundation, growing evidence supports the routine evaluation of folate status among medically ill, depressed patients and patients with chronic and/or treatment-refractory depression. In these settings, supplementation with folate or its derivative, methylfolate, may be found to play an important role in effective antidepressant treatment.


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