Chromosomal Abnormalities and Bipolar Affective Disorder: Velo-Cardio-Facial Syndrome

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Medscape Psychiatry & Mental Health eJournal. 1997;2(4) 

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Darier's Disease

In 1995, Dawson and colleagues[26] described a Welsh family in which they reported a cosegregation of major affective disorder with Darier's disease, an autosomal dominant skin disorder mapped to the short arm of chromosome 12 (12q23-q24.1). Their study of the segregation of 7 markers spanning the Darier's disease locus in 45 bipolar disorder pedigrees found modest support of linkage for 5 of these markers. The sample had relatively low power to detect linkage, and replication studies with independent sets of pedigrees will be necessary in order to confirm the possibility that a susceptibility gene resides in this locus, or chromosomal region.


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