The American Psychiatric Association Practice Guideline for the Treatment of Patients With Panic Disorder: Recommendations and Controversies

Fredric N. Busch, MD and Barbara L. Milrod, MD

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No studies of the use of MAOIs for the treatment of panic have been done since the panic disorder diagnosis was introduced in 1980, and there is significant concern about their adverse effects. Minimal data suggest that venlafaxine, nefazadone, valproic acid, calcium channel blockers, and inositol are effective in panic treatment. The results have been mixed for trazodone, propranolol, and clonidine; bupropion and carbamazepine are considered not to be effective for treatment of panic.[1,30,31,32,33,34,35,36,37,38,39,40,41]

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