Variable physiologic changes, increased risk for drug-drug interactions, and comorbid diseases in elderly patients unpredictably alter AED response. Consequently, it is particularly important to select an AED based on individual patient conditions and the drug's pharmacologic profile. Therapy is generally complicated by limited reliable dosage guidelines, especially for individuals more than 75 years of age. Lower starting dosages and more gradual dosage escalation than in younger patients are indicated for several AEDs. Extraordinary attention to continued drug need and heightened awareness of adverse drug reactions and interactions are warranted since the symptoms of prevalent comorbid conditions can mimic those of seizure disorders and adverse AED reactions.
Supported by an unrestricted education grant from Abbott Pharmaceuticals, Chicago, Illinois.
Address reprint requests to Thomas E. Lackner, Pharm.D., College of Pharmacy, University of Minnesota, Weaver-Densford Hall, Suite 7-115E, 308 Harvard Street SE, Minneapolis, MN 55455.
Pharmacotherapy. 2002;22(3) © 2002 Pharmacotherapy Publications
Copyright © 1999, Pharmacotherapy Publications, Inc., All rights reserved.
Cite this: Strategies for Optimizing Antiepileptic Drug Therapy in Elderly People - Medscape - Mar 01, 2002.