Curr Med Res Opin. 2001;17(1s) 

In This Article

Anti-emetics in Clinical Practice

Anti-emetics are useful for the treatment of nausea and vomiting accompanying headache. For mild or moderate symptoms, phenothiazines or antihistamines may suffice and are widely available without prescription. Dopamine and 5-HT3 antagonists such as metoclopramide and domperidone have the added advantage of promoting absorption of oral analgesics, which can enhance efficacy. Domperidone alone may be effective if taken during the prodrome of migraine. If nausea or vomiting precludes oral medication, rectal anti-emetics should be used. Intramuscular chlorpromazine can be considered for emergency acute treatment. Empirical data suggest that combining these agents with triptans may also offer additional benefit but formal clinical trials are necessary to confirm this.


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